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MetabolomicsGREM1 Deficiency induced Bone Marrow Adipose Niche promotes B-cell Acute Lymphoblastic Leukemia Disease Progression
Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, the bone marrow adipose microenvironment is commonly observed in pediatric leukemia. However, the relationshi...
2024-09-23 | MTBLS10103 | MetaboLights
MetabolomicsInhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass
Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...
2024-06-17 | MTBLS9415 | MetaboLights
MetabolomicsHarnessing Exogenous Stimuli and Functionally 3D Aligned Fibrous Scaffolds for Spatiotemporal Modulation of Bone Regeneration

Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...

2026-03-04 | MTBLS13974 | MetaboLights
TranscriptomicsTranscription profiling of human bone marrow derived and trabecular bone osteogenic cells - 0
This SuperSeries is composed of the following subset Series:; GSE12264: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone I; GSE12265: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone II; GSE12266: Gene Expres...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12267 | biostudies-arrayexpress
TranscriptomicsExpression profile in bone marrow Nestin-GFP cells
Expression profile analysis in steady-state bone marrow-derived GFP+ cells obtained from transgenic mice in which GFP expression is regulated under the nestin gene promoter Three replicates
ORGANISM(S): Mus musculus 
2010-07-15 | E-GEOD-21941 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mesenchymal stem cells exposed to CM from tumor cells or bone marrow
Gene Expression profile of MSCs exposed to CM from tumor cells or bone marrow.
ORGANISM(S): Rattus norvegicus 
2006-05-30 | E-MEXP-532 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteogenic cells derived from bone marrow and trabecular bone - II
The aim of this study was to describe the gene expression patterns related to the differentiation and mineralization of bone-forming cells, including activation and/or repression of osteogenic or non-osteogenic pathways, remodeling of cell architecture, cell adhesion, cell communication, and assembl...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12265 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells from adipose tissue grown in normal media in monolayer or with LVG or RGD alignate
Experiment to see the effect of regular and RGD alginate on MSC derived from bone marrow and adipose tissue
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1273 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of human bone marrow cells enriched using RNA probes
Gene expression profiles of individual bone marrow cells were acquired by Drop-Seq. Subsets of bone marrow cells were isolated using fluorescence-assisted cell sorting to enrich for putative skeletal stem cells.
ORGANISM(S): Homo sapiens 
2022-05-31 | E-MTAB-9664 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of human bone marrow cells enriched for stromal and endothelial markers
Gene expression profiles of individual bone marrow cells were acquired by Drop-Seq. Subsets of bone marrow cells were isolated using magnetic cell sorting to enrich for putative skeletal stem cells.
ORGANISM(S): Homo sapiens 
2021-06-30 | E-MTAB-9662 | biostudies-arrayexpress
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