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Organisms

Mus musculus (1024)
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unidentified (3)
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mouse gut metagenome (2)
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Human immunodeficiency virus (1)
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Nothobranchius furzeri (1)
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Oncorhynchus mykiss (1)

Repository

biostudies-arrayexpress (9055)
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pride (241)
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Tissue

Bone marrow (83)
Liver (36)
Lung (35)
Kidney (30)
Brain (30)
Spleen (28)
Heart (27)
Colon (26)
Testis (21)
Pancreas (20)
Lymph node (18)
Stomach (16)
Ovary (15)
Placenta (14)
Adrenal gland (14)
Small intestine (13)
Duodenum (7)
Esophagus (7)
Prostate gland (7)
Zone of skin (6)
Uterus (6)
Urinary bladder (6)
Endometrium (5)
Adipose tissue (5)
Thymus (5)
Rectum (5)
Gall bladder (5)
Breast (5)
Cerebral cortex (5)
Pituitary gland (5)

Disease

Normal (84)
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Rhabdomyosarcoma (2)
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Pancreatic carcinoma (2)
Ovarian carcinoma (2)
Lung carcinoma (2)
Non-small cell lung carcinoma (2)
Plasmacytoma (2)
Renal cell carcinoma (2)
Pancreatic adenocarcinoma (2)
Lymphoma (2)
Gastric adenocarcinoma (2)
Glioma (2)
Squamous cell lung carcinoma (2)
Cervical squamous cell carcinoma (2)
Ovarian adenocarcinoma (2)

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Mass Spectrometry (245)
Mass spectrometry (159)
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Mass spectrometry assay (120)
Bottom-up proteomics (49)
Data-independent acquisition (24)
Data-dependent acquisition (23)
Illumina HiSeq 2000 (19)
SWATH MS (11)
Gel-based experiment (10)
NMR spectroscopy (7)
ESI (4)
Illumina HiSeq 2500, ILLUMINA (3)
ILLUMINA, Illumina HiSeq 2000 (3)
Illumina HiSeq 2500 (2)
Illumina MiSeq, Illumina HiSeq 2000, ILLUMINA (1)
Illumina HT12, Affymetrix miRNA 4.0 Array (1)
Combined on identical nucleotide universal identifier, Illumina HumanWG-6 version 3 or Illumina HumanHT-12 expression bead chip (1)
Illumina HiSeq 2000, HiSeq X Ten, Illumina HiSeq 2500, ILLUMINA (1)
NextSeq 500, Illumina HiSeq 2500, ILLUMINA (1)
ILLUMINA, NextSeq 500 (1)
Illumina HiSeq 4000, ILLUMINA (1)
Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
HiSeq X Ten, ILLUMINA (1)
Illumina HiSeq 2000, Infinium HumanMethylation450 BeadChip (1)
Illumina HiSeq 2000, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, ILLUMINA (1)
Illumina Genome Analyzer II (1)
NMR spectroscopy assay (1)

Instrument Platform

Illumina NovaSeq 6000 (237)
Illumina HiSeq 2500 (111)
NextSeq 500 (108)
Illumina HiSeq 4000 (103)
Illumina HiSeq 2000 (100)
NextSeq 550 (34)
Axon GenePix 4000B scanning hardware (29)
Scanning hardware (22)
NextSeq 2000 (20)
Axon GenePix 4000A scanning hardware (19)
GenePix 4000B [Axon Instruments] (16)
Axon- GenePix4000B (15)
Illumina MiSeq (15)
GenePix 4000A [Axon Instruments] (13)
Illumina Genome Analyzer IIx (13)
Illumina NovaSeq X (13)
Illumina Genome Analyzer II (11)
Illumina HiSeq 1500 (11)
NA (10)
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N/A (9)
G2565AA DNA microarray scanner [Agilent] (8)
DNBSEQ-G400 (8)
Illumina HiSeq 3000 (8)
GenePix Personal 4100A [Axon Instruments] (6)
GenePix Professional 4200A [Axon Instruments] (6)
Other (6)
G2565BA DNA microarray scanner [Agilent] (6)
ScanArray Express HT [PerkinElmer] (6)
ArrayWoRx Biochip Reader [Applied Precision] (5)

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2010 (1315)
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2026 (434)
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2007 (333)
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2005 (296)
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2006 (270)
2021 (227)
2020 (198)
2019 (160)
2018 (153)
2017 (129)
2004 (78)
2003 (9)
2002 (1)
2027 (1)

UNIPROT ID/AC

1433E_SHEEP (6)
1433Z_SHEEP (6)
6PGD_SHEEP (6)
A1AT_SHEEP (6)
A8DR93_SHEEP (6)
AL1A1_SHEEP (6)
ALBU_SHEEP (6)
ANT3_SHEEP (6)
ANXA2_SHEEP (6)
CERU_SHEEP (6)
COF1_SHEEP (6)
FETUA_SHEEP (6)
G3P_SHEEP (6)
HBB_SHEEP (6)
IDHC_SHEEP (6)
PDXK_SHEEP (6)
PLMN_SHEEP (6)
SODC_SHEEP (6)
THIO_SHEEP (6)
TTHY_SHEEP (6)
W5NPN4_SHEEP (6)
W5NQ45_SHEEP (6)
W5NUE3_SHEEP (6)
W5NUN8_SHEEP (6)
W5NUX8_SHEEP (6)
W5NVC9_SHEEP (6)
W5NXN2_SHEEP (6)
W5NY95_SHEEP (6)
W5NYA7_SHEEP (6)
W5P1X9_SHEEP (6)

ENSEMBL ID

ENSG00000170477 (1)

CHEBI ID

CHEBI:16737 (29)
CHEBI:28865 (13)
CHEBI:16675 (9)
CHEBI:15627 (1)
CHEBI:3110 (1)
CHEBI:16874 (1)
CHEBI:16565 (1)
CHEBI:27515 (1)
CHEBI:36528 (1)
CHEBI:15958 (1)
CHEBI:17927 (1)
CHEBI:28101 (1)
CHEBI:28743 (1)
CHEBI:6801 (1)
CHEBI:18318 (1)
CHEBI:16796 (1)
CHEBI:17687 (1)
CHEBI:42820 (1)
CHEBI:28247 (1)
CHEBI:36274 (1)
CHEBI:28058 (1)
CHEBI:27691 (1)
CHEBI:17292 (1)
CHEBI:16091 (1)
CHEBI:28648 (1)
CHEBI:28175 (1)
CHEBI:18163 (1)
CHEBI:17364 (1)
CHEBI:17474 (1)
CHEBI:37463 (1)

Metabolite Name

Hypoxanthine (56)
Taurine (55)
Creatine (53)
Adenosine (49)
Xanthine (49)
Creatinine (49)
Adenine (48)
Uracil (45)
Uridine (44)
Inosine (44)
Guanosine (42)
L-Tyrosine (40)
Guanine (38)
Thymine (36)
Choline (36)
Xanthosine (36)
L-Phenylalanine (36)
L-Histidine (35)
Riboflavin (35)
Cytidine (34)
Citrulline (33)
L-Glutamine (33)
Glycine (32)
Betaine (32)
Ornithine (32)
Citric acid (32)
Malic acid (32)
Cytosine (32)
Phenylalanine (32)
Uric acid (32)

First Public Date

2025 (296)
2024 (283)
2026 (282)
2014 (259)
2023 (178)
2021 (159)
2022 (137)
2020 (114)
2019 (94)
2017 (63)
2018 (59)
2015 (57)
2016 (32)
2013 (21)
2011 (1)

Modelling Approach

Ordinary differential equation model (2)
Partial differential equation model (1)

Study status

Completed (17)
Recruiting (6)
Terminated (3)
Withdrawn (2)
Not yet recruiting (2)
Active, not recruiting (1)

Lab affiliation

Division of Cell Matrix Biology & Regenerative Medicine (L5) / Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester (6)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (4)
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, UK (4)
1) Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; 2) Institute for Bioanalysis, University of Applied Science Coburg, Coburg, Germany (2)
All India Institute of Medical Sciences, New Delhi, India (2)
Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (2)
The University of Melbourne (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
Wellcome Trust Sanger Institute (2)
1 Department of Medicine - Western Health, The University of Melbourne, Melbourne, Australia The Australian Institute for Musculoskeletal Science (AIMSS), Western Health, Victoria University and The University of Melbourne, Melbourne, Australia 3 Institute for Health and Sport, Victoria University, Melbourne, Australia (1)
1 Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada 2 Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A5, Canada (1)
1) Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA 2) Proteomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA 3) Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA (1)
1. Ludwig Boltzmann Institute for Traumatology The research center in cooperation with AUVA, Donaueschingenstrasse 13, 1200 Vienna, Austria 2. Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200 Vienna, Austria (1)
1Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (1)
Aalborg University Laboratory for Medical Massspectrometry (1)
Aalborg University; Translational biomarkers (1)
Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China (1)
Affiliation* Key Laboratory of Genetics and Breeding, Zhejiang Institute of Freshwater Fisheries, Huzhou, China (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Assistant Professor, Department of Biochemistry, University of Calcutta, Kolkata, India (1)
Assistant Professor, Physiology and Pharmacology, University of Calgary, McCaig Insitute for Bone and Joint Health (1)
Associate Professor, Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka (State),India (C) (1)
Basilbiotech, Incheon 22002, Republic of Korea. (1)
Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar, Technical University of Munich (1)
Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, 10115, Berlin, Germany (1)
BioArCh, University of York, UK (1)
BioArCh, University of York, United Kingdom (1)
CECAD and Institute for Genetics Joseph-Stelzmann Straße 26 University of Cologne, Cologne, Germany (1)
CIR, Queen’s Medical Research Institute, University of Edinburgh (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)

Keyword

Cyclosporine (7)
Cyclosporins (7)
Mycophenolic Acid (5)
Fludarabine (5)
Fludarabine phosphate (5)
Cyclophosphamide (4)
Etoposide (4)
Etoposide phosphate (4)
Busulfan (3)
Tacrolimus (2)
Stage IV uterine sarcoma (2)
Recurrent uterine sarcoma (2)
Recurrent adult soft tissue sarcoma (2)
Stage IV adult soft tissue sarcoma (2)
Methotrexate (2)
Antineoplastic Agents, Immunological (2)
Antibodies (2)
Immunoglobulins (2)
Antibodies, Monoclonal (2)
Gamma Secretase Inhibitors and Modulators (1)
2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1)
Bendamustine Hydrochloride (1)
Precision Medicine (1)
Molecular Sequence Data (1)
Databases, Genetic (1)
High-Throughput Nucleotide Sequencing (1)
Massively-Parallel Sequencing (1)
Patient Outcome Assessment (1)
Adaptive clinical trial (1)
Molecular Typing (1)

IsPrivate

False (4)

Model Flag

Non Kinetic (1)

Classification

bacteria (2)
viruses (1)
fungi (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (5244)
RNA-seq of coding RNA (688)
ChIP-seq (651)
ChIP-chip by tiling array (619)
Unknown experiment type (424)
Comparative genomic hybridization by array (234)
RNA-seq of coding RNA from single cells (169)
Methylation profiling by array (168)
Other (137)
ChIP-chip by array (83)
Methylation profiling by high throughput sequencing (75)
RNA-seq of non coding RNA (71)
Transcription profiling by RT-PCR (50)
Genotyping by array (46)
DNA-seq (41)
RNA-seq of total RNA (30)
MicroRNA profiling by array (27)
Single nucleus RNA sequencing (23)
Animal - High-throughput sequencing (22)
Spatial transcriptomics by high-throughput sequencing (19)
Cell line - High-throughput sequencing (17)
Transcription profiling by tiling array (14)
RNAi profiling by array (14)
Transcription profiling by SAGE (13)
Human - High-throughput sequencing (13)
ATAC-seq (13)
Proteomic profiling by array (12)
MicroRNA profiling by high throughput sequencing (10)
Animal - One-color microarray (8)
Human - One-color microarray (7)

Release Date

2022 (1984)
2023 (1798)
2025 (1784)
2021 (1782)
2013 (1606)
2024 (1511)
2020 (1478)
2010 (1463)
2015 (1364)
2014 (1293)
2016 (1154)
2019 (1135)
2018 (1113)
2011 (1111)
2012 (1081)
2017 (861)
2008 (635)
2009 (570)
2026 (394)
2007 (380)
2005 (337)
2006 (319)
2004 (95)
2003 (24)
2002 (9)
1998 (6)
2001 (5)
2000 (5)
1999 (4)
1997 (2)

Location

United States (26)
Australia (5)
Italy (3)
Germany (2)
India (1)
United Kingdom (1)
Japan (1)
France (1)

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Inhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass

Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...

2024-06-17 | MTBLS9415 | MetaboLights

Untargeted LC–MS Metabolomic Analysis of Connexin 43 in Bone Metabolism

MC3T3-E1 cells were divided into two groups: si-NC and si-Connexin43. Cx43 expression was knocked down using siRNA transfection, followed by LC–MS-based untargeted metabolomic analysis to investigate metabolic alterations associated with Connexin 43 deficiency in osteoblasts and its potential rol...

2026-09-29 | MTBLS14532 | MetaboLights

Strontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating gut-liver-bone axis: The TD chicken model

This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate ...

2025-09-25 | MTBLS13045 | MetaboLights

Strontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating gut-liver-bone axis: The TD chicken model

2025-09-24 | MTBLS13038 | MetaboLights

Harnessing Exogenous Stimuli and Functionally 3D Aligned Fibrous Scaffolds for Spatiotemporal Modulation of Bone Regeneration

Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...

2026-03-04 | MTBLS13974 | MetaboLights

Metabolic-engineered probiotic-OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy

Chronic, drug-resistant bone infection caused by methicillin-resistant Staphylococcus aureus (MRSA) features an immunosuppressive niche enabling persistent infection and impaired bone healing. Specific treatment requires initial antibacterial immune activation against infection, followed by resha...

2026-03-19 | MTBLS14091 | MetaboLights

The gut microbiome has sexually dimorphic effects on bone tissue energy metabolism and multiscale bone quality in C57BL/6J mice

Not available

ORGANISM(S): Mus musculus

ST002342 | MetabolomicsWorkbench

Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...

2025-10-30 | MTBLS13141 | MetaboLights

Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer

Bone metastasis is a lethal consequence of breast cancer. AT-rich interaction domain 1A gene (ARID1A), a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, regulates immunosuppressive tumor microenvironment. ARID1A deficient triple negative breast cancer promotes bone metastasis.To ...

2026-03-24 | MTBLS12768 | MetaboLights

GREM1 Deficiency induced Bone Marrow Adipose Niche promotes B-cell Acute Lymphoblastic Leukemia Disease Progression

Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, the bone marrow adipose microenvironment is commonly observed in pediatric leukemia. However, the relationshi...

2024-09-23 | MTBLS10103 | MetaboLights