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MetabolomicsHarnessing Exogenous Stimuli and Functionally 3D Aligned Fibrous Scaffolds for Spatiotemporal Modulation of Bone Regeneration

Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...

2026-03-04 | MTBLS13974 | MetaboLights
TranscriptomicsPredicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To th...
ORGANISM(S): Homo sapiens 
2018-10-04 | E-MTAB-7210 | biostudies-arrayexpress
ProteomicsBone proteomics methods optimisation for forensic investigations
The application of human bone in forensic proteomics is an expanding novel purpose in the aim of successfully quantifying biological estimations used in medico-legal investigations with greater accuracy. In this project, different extraction protocols were tested on n=30 human bone samples, includi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-10 | MSV000093803 | MassIVE
TranscriptomicsTranscription profiling by array of human trabecular bone osteogenic cells
The aim of this study was to describe the gene expression patterns related to the differentiation and mineralization of bone-forming cells, including activation and/or repression of osteogenic or non-osteogenic pathways, remodeling of cell architecture, cell adhesion, cell communication, and assembl...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12264 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteogenic cells derived from bone marrow and trabecular bone - II
The aim of this study was to describe the gene expression patterns related to the differentiation and mineralization of bone-forming cells, including activation and/or repression of osteogenic or non-osteogenic pathways, remodeling of cell architecture, cell adhesion, cell communication, and assembl...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12265 | biostudies-arrayexpress
ProteomicsComparative intraindividual proteomic analysis of osteogenic differentiated adipose tissue-derived and bone marrow-derived mesenchymal stem cells reveals integrin expression profile as distinctive feature
The treatment of bone defects caused by infection, trauma or neoplasms remains a clinical challenge. Autologous bone transplantation is limited by availability, donor site morbidity and surgical risk factors. This has given rise to stromal/stem-cell based therapy. Bone marrow derived stromal cells (...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD015223 | Pride
Dia-based proteomics Bone defect Osteogenic differentiated human stem cells Integrin 
TranscriptomicsTranscription profiling of human bone marrow derived and trabecular bone osteogenic cells - 0
This SuperSeries is composed of the following subset Series:; GSE12264: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone I; GSE12265: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone II; GSE12266: Gene Expres...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12267 | biostudies-arrayexpress
UnknownTissue Engineering with Compact Bone-Derived Cell Spheroids Enables Bone Formation around Transplanted Tooth.
Not available
S-EPMC8971212 | biostudies-literature
TranscriptomicsTranscription profiling by array of MG-63 cells grown on different biomaterials used in bone grafts
During the past decades, there have been major advances in the field of biomaterials, thereby generating a vast variety of materials for a broad range of tissue engineering and regeneration applications. Although gene expression profiling has been used occasionally in biomaterial research, its usefu...
ORGANISM(S): Homo sapiens 
2018-10-05 | E-MTAB-7219 | biostudies-arrayexpress
TranscriptomicsA calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca2+ released from these c...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7222 | biostudies-arrayexpress
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