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TranscriptomicsHIF-1 dependent gene expression upon S. aureus infection
HIF-1 is an important transcription factor for immune responses to bacterial infection. We wanted to analyze the HIF-1 dependent gene expression upon S. aureus infection and analyzed the gene expression of HepG2 nt and HepG2 HIF-1-/- cells four hours upon infection using affymetrix human gene 1.0 st...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-44943 | biostudies-arrayexpress
TranscriptomicsAlpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization
Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movemen...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-19534 | biostudies-arrayexpress
TranscriptomicsImmune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E
Microarray analysis and quantitative real-time PCR revealed that TB40E infection of DCs led to changes of the gene expression pattern. A variety of pro-inflammatory cytokines and chemokines (CXCL10, CXCL11, CCL5), TLR3 and genes whose products function downstream of the TLR3 signalling pathway (e.g....
ORGANISM(S): Homo sapiens 
2009-08-01 | E-GEOD-14816 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of the Retina after Transcorneal Electrical Stimulation in Wildtype Brown Norway Rats
Purpose: To investigate the effect of transcorneal electrical stimulation (TES) on the retina of wildtype Brown Norway (BN) rats by gene expression profiling. Methods: TES was applied to BN adult wildtype rat retina in vivo for 1h (1ms biphasic pulses at 20Hz; current: 200 M-BM-5A). RNA was isolated...
ORGANISM(S): Rattus norvegicus 
2011-11-21 | E-GEOD-26174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of retinae from wildtype and retinoschisin knockout mice (Rs1h-/Y) at postnatal day 7 to understand the effect of retinoschisin on gene expression
Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Experiment Overall Design: RNAs from retinae from 3 Wildtype Mice versus 3 Retinoschisin-KO mice (Rs1h-/Y) at postnatal day 7 (P7) were hybridized onto Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5581 | biostudies-arrayexpress
TranscriptomicsPediatric Hepatocellular Carcinoma Celll Line
Development of a new carcinoma cell line (HC-AFW1) derived from a pediatric liver tumor The cell line HC-AFW1 was derived from a 4 year old boy suffering from HCC through culturing and passage into immuno-deficient mice. The cell line is stable now for over 8 months of culture with a doubling time...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-29283 | biostudies-arrayexpress
TranscriptomicsGenotyping data from one patient with unexplained mental retardation and a deletion in 15q13
Recurrent deletions on 15q13.3 have been identified as a predisposition to mental retardation, epilepsy and psychiatric disease. We report compound heterozygous deletions on 15q13.3 in one patients with severe encephalopathy and seizures. We analysed two independent patients with severe encephalopat...
ORGANISM(S): Homo sapiens 
2011-03-05 | E-GEOD-20564 | biostudies-arrayexpress
TranscriptomicsBlood expression profiles define penetrance in DYT1 dystonia patients
DYT1 dystonia is an autosomal-dominantly inherited movement disorder, which is usually caused by a GAG deletion in the TOR1A gene. Due to the reduced penetrance of ~30-40%, the determination of the mutation in a subject is of limited use with regard to actual manifestation of symptoms. In the presen...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-19419 | biostudies-arrayexpress
TranscriptomicsGenotyping data from one patient with unexplained mental retardation and a deletion in 11q13.3-q13.4
We report a deletion on 11q13.3-q13.4 in one patients with severe mental retardation. We analyzed a patient with mental retardation and the related parents with a whole genome SNP Array.
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20533 | biostudies-arrayexpress
TranscriptomicsTranscriptomics changes in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate
Studying chemical disturbances during neural differentiation of mES cells has been established as an alternative in vitro testing approach for the identification of developmental toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing thei...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-50215 | biostudies-arrayexpress
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