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TranscriptomicsATAC-seq on endocardial cells from E12.5 mouse hearts in Tbx20 knockouts and wild type counterparts
We used ATAC-seq (Buenrostro et al, 2013) to identify regions of open chromatin in FACS sorted mouse endothelial cells from E12.5 hearts. Please note that the animals were injected at different dates, which resulted in different effects of the knockout, as indicated in the batch attribute of the s...
ORGANISM(S): Mus musculus 
2017-06-02 | E-MTAB-3972 | biostudies-arrayexpress
UnknownClinical nodal staging to assess the risk of local recurrence after rectal cancer resection: A nationwide cross-sectional study.

Aim

In rectal cancer, neo-adjuvant (chemo)radiotherapy (n(C)RT) should be used selectively, due to related toxicity. The decision to offer n(C)RT is mainly based on preoperative MRI staging. cN category has limited accuracy and its use when deciding on n(C)RT is controversial. This populatio...
S-EPMC12508276 | biostudies-literature
GenomicsChIP-seq of Tbx20 tagged with GFP in E11.5 mouse hearts
We performed ChIP-seq of Tbx20 tagged with GFP in mouse hearts to identify binding sites for this transcription factor. This data set is part of the study “Endocardial Tbx20 is essential for mesenchymal and myocardial cell movements required for cardiac septation”.
ORGANISM(S): Mus musculus 
2016-06-30 | E-MTAB-3967 | biostudies-arrayexpress
UnknownCommon Genetic Variants Contribute to Risk of Transposition of the Great Arteries.

Rationale

Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart defect which affects approximately 1 in 4,000 live births. While there are several reports of D-TGA patients with rare variants in individual genes, the majority of D-TGA cases remain genetically elusiv...
S-EPMC8768504 | biostudies-literature
ProteomicsProtein aggregation is an early manifestation of phospholamban p.(Arg14del)-related cardiomyopathy
Background: The p.(Arg14del) pathogenic variant (R14del) of the phospholamban (PLN) gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying pathophysiology is unknown, and a suitable therapy is unavailable. We aim to identify molecular perturbations underlying this cardi...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD024594 | Pride
Inherited cardiomyopathy Heart failure Phospholamban Protein aggregation 
UnknownAn updated evaluation of the implementation of the sigmoid take-off landmark 1 year after the official introduction in the Netherlands.

Purpose

The definition of rectal cancer based on the sigmoid take-off (STO) was incorporated into the Dutch guideline in 2019, and became mandatory in the national audit from December 2020. This study aimed to evaluate the use of the STO in clinical practice and the added value of online tra...
S-EPMC10638143 | biostudies-literature
UnknownOncological outcomes of planned and unplanned low Hartmann's procedure and restorative low anterior resection for rectal cancer: a population-based cross-sectional study.

Background

In the Netherlands, approximately 15% of patients with rectal cancer undergo a low Hartmann's procedure (low-HP). This is often preoperatively planned to avoid poor functional outcome or complications, but might be unplanned as a result of intraoperative difficulties. Low-HPs seem...
S-EPMC12678588 | biostudies-literature
UnknownAbandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes.

Importance

Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application...
S-EPMC10739079 | biostudies-literature
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