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MetabolomicsPolyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis a...

2025-07-24 | MTBLS12633 | MetaboLights
TranscriptomicsAnalysis of wildtype and Csnk2b-deficient Foxp3+ regulatory T cells transcriptomes
The goal of this study was to compare the transcriptional changes evoked by Csnk2b-deficiency in Foxp3+ regulatory T cells Messenger RNA profiles of CD4+Foxp3+ regulatory T cells isolated from 8 week old wild type (WT) and Csnk2b-deficient mice were generated by deep sequencing in duplicate, using I...
ORGANISM(S): Mus musculus 
2015-01-13 | E-GEOD-63961 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human regulatory and helper T cells following activation with anti-CD3 and anti-CD28 for 4 and 16 hours
Primary non-expanded human T cell populations were isolated by leukapheresis from 10 healthy donors. Out of each donor > 95% pure CD4-positive Th cell and >95% pure regulatory T cell populations were purified. Two affymetrix exon arrays were hybridized from each donor both populations as resting, no...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-TABM-779 | biostudies-arrayexpress
TranscriptomicsAnalysis of bone marrow derived mast cell transcriptomes in presence or absence of SialostatinL
Goal of this study was to compare transcriptional changes in stimulated mast cells in the absence or presence of sialostatinL mRNA profiles of 4 weeks old mast cells (BMMC derived from C57BL/6 mice ) stimulated for 24h with ionomycin in absence or presence of tick derived sialostatinL were generated...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-66966 | biostudies-arrayexpress
ProteomicsElucindating the role of the transcription factor IRF4 in Th17 and Treg cells
- transcription factor interferon regulatory factor 4 (IRF4) = crucial transcription factor for different immune cells, incl pro-inflammatory Th17 and anti-inflammatory Treg cells - IRF4 is essential for the cell differentiation and fate determination - however molecular mechanisms of IRF4-mediated...
ORGANISM(S): Mus Musculus (mouse) 
2024-08-02 | PXD044298 | JPOST Repository
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