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UnknownHigh long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adults.
In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outsid...
S-EPMC7446562 | biostudies-literature
UnknownAssociations between inflammation and striatal dopamine D2-receptor availability in aging.

Background

Normal brain aging is associated with dopamine decline, which has been linked to age-related cognitive decline. Factors underlying individual differences in dopamine integrity at older ages remain, however, unclear. Here we aimed at investigating: (i) whether inflammation is assoc...
S-EPMC11783874 | biostudies-literature
UnknownEffects of controlled supramaximal high-intensity interval training on muscle capacities and physical functions for older adults: analysis of secondary outcomes from the Umea HIT study-a randomised controlled trial.

Objective

This study investigated the effectiveness of supramaximal high-intensity interval training (supramaximal HIT) on muscle capacities and physical function compared to moderate-intensity training (MIT) for older adults.

Methods

Sixty-eight older adults (66-79 years, 56% women),...
S-EPMC11471315 | biostudies-literature
UnknownEffects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT): study protocol for a multi-centre, randomized controlled trial.

Background

Beyond being a pulmonary disease, chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in the non-pharmacological treatment of COPD, the...
S-EPMC11460198 | biostudies-literature
UnknownImprovement in indices of cellular protection after psychological treatment for social anxiety disorder.
Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, G...
S-EPMC6920472 | biostudies-literature
UnknownVoxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder.
Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in vari...
S-EPMC6103329 | biostudies-literature
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