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TranscriptomicsSingle-cell RNA sequencing of marmoset embryonic development
Transcriptional profiling of common marmoset embryo stages spanning zygote to late preimplantation blastocyst was performed by single-cell RNA-seq.
ORGANISM(S): Callithrix jacchus 
2018-11-01 | E-MTAB-7078 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of mouse embryonic day 3.5 blastocyst inner cell mass cells
Inner cell mass (ICM) cells of two independent E3.5 blastocysts were profiled by transcriptome sequencing to assess the expression of extracellular matrix components.
ORGANISM(S): Mus musculus 
2014-05-15 | E-MTAB-2555 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human trophoblast stem cells as a model of trophoblast-cytotrophoblast (TB-CTB)
Placenta derived Okae et al. human trophoblast stem cells cultured in Okae et al. conditions (ttps://doi.org/10.1016/j.stem.2017.11.004). In addition, we sequenced SHEF6 primed human pluripotent stem cells as a control. Individual cells were manually isolated with a mouth pipette and subjected to s...
ORGANISM(S): Homo sapiens 
2022-06-03 | E-MTAB-10890 | biostudies-arrayexpress
TranscriptomicsSpatial Embryo Profiling of primate gastrulation
We investigated marmoset gastrulation using SpaTial Embryo Profiling (STEP) to generate 3D-transcriptomes based on the physical location of samples within the implanted embryo. Samples were isolated from unfixed tissues using laser-capture-microdissection and subjected to single-cell full-lengths tr...
ORGANISM(S): Callithrix jacchus 
2022-02-14 | E-MTAB-9367 | biostudies-arrayexpress
TranscriptomicsPrimed and naïve marmoset pluripotent stem cells as a model for primate development
We derived primed pluripotent stem cell cultures (PSCs) from marmoset blastocyst using conventional human PSC culture conditions (KSR/bFGF on feeders). Naïve marmoset PSCs were established by chemical resetting. In addition, we generated forebrain-derived cells from the frontal lobe of a marmoset ne...
ORGANISM(S): Callithrix jacchus 
2022-02-14 | E-MTAB-9349 | biostudies-arrayexpress
TranscriptomicsMarmoset epiblast and amnion spheroids as models for postimplantation lineage specification
We encapsulated common marmoset pluripotent stem cells (cmPSCs) in agarose microgels and optimised culture conditions to generate epiblast and amnion spheroids. Using this system, we investigate the effects of signalling perturbations on epiblast and amnion spheroids as a model for early lineage spe...
ORGANISM(S): Callithrix jacchus 
2022-07-06 | E-MTAB-10639 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of marmoset embryonic development
Transcriptional profiling of common marmoset embryo stages spanning E5.0 to E7.0 was performed by RNA-seq.
ORGANISM(S): Callithrix jacchus 
2015-11-05 | E-MTAB-2959 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of mouse embryonic development
Transcriptional profiling of mouse embryos spanning the 8-cell morula stage to E5.5 postimplantation epiblast was performed using lineage-specific RNA-seq.
ORGANISM(S): Mus musculus 
2015-11-09 | E-MTAB-2958 | biostudies-arrayexpress
TranscriptomicsHuman and marmoset trophoblast stem cells differ in signalling requirements and recapitulate divergent modes of trophoblast invasion
We derive experimental conditions for the derivation of marmoset trophoblast like cells. Marmoset naïve PSC form extraembryonic mesoderm in human TSC conditions, whilst TGFβ/NODAL, FGF/ERK and WNT signalling control marmoset peri- and postimplantation trophoblast identity.
ORGANISM(S): Callithrix jacchus 
2024-11-21 | E-MTAB-12463 | biostudies-arrayexpress
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