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TranscriptomicsTranscription profiling of human umbilical vein endothelial cells treated with Interferon-gamma (IFN-g), Borrelia burgdorferi or both IFN-g and Borrelia or untreated to investigate immune responses to Lyme disease
Borrelia burgdorferi, the agent of Lyme disease, promotes pro-inflammatory changes in endothelium that lead to the recruitment of leukocytes. The host immune response to infection results in increased levels of IFN-gamma in the serum and lesions of Lyme disease patients that correlate with greater s...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6092 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the Borrelia burgdorferi bb0647 mutant
RNA was isolated from late-log pahse wild-type Borrelia burgdorferi B31 and the bb0647 mutant grown in BSKH media at 37 degree, 5% CO2. cDNA was synthesized, labeled and hybridized to the 70mer oligonucleotide B. burgdorferi array. Slides were scanned using axon scanner and image were analyzed using...
ORGANISM(S): Borrelia burgdorferi 
2010-05-15 | E-GEOD-17422 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of normal human dermal fibroblasts (NHDF) induced by Borrelia burgdorferi sensu stricto
The aim of the study was to compare the global transcriptional responses elicited in NHDF cells by three different strains of Borrelia burgdorferi ss (the agent of Lyme borreliosis), representative of different stages in the life cycle of Borrelia: one reference strain isolated from a tick (strain ...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-31740 | biostudies-arrayexpress
ProteomicsIdentification of the effect of a CRISPR interference knockdown of Borrelia burgdorferi strain B31 BB0838, a outer membrane lipoprotein flippase candidate, on surface lipoprotein secretion using Multidimensional Protein Identification Technology.
To identify the effect of a CRISPR interference knockdown of Borrelia burgdorferi strain B31 BB0838, a outer membrane lipoprotein flippase candidate, on surface lipoprotein secretion using Multidimensional Protein Identification Technology.
ORGANISM(S): Borrelia Burgdorferi B31 (ncbitaxon:224326) 
2022-07-27 | MSV000089990 | MassIVE
ProteomicsProteomic Analysis of Lyme Disease: Global Protein Comparison of Three Strains of Borrelia Burgdorferi
We report the proteomic analysis of the archetype B. burgdorferi B31 strain and two other strains (ND40, and JD-1) having different Borrelia pathotypes using strong cation exchange fractionation of proteolytic peptides followed by high-resolution, reversed phase capillary liquid chromatography coupl...
ORGANISM(S): Borreliella Burgdorferi (ncbitaxon:139) 
2020-05-29 | MSV000085503 | MassIVE
TranscriptomicsComparison between Borrelia burgdorferi wild type strain and cognate rpoS, rpoN and rrp2 mutants
The RpoN-RpoS alternative sigma factor pathway is essential for key adaptive responses by Borrelia burgdorferi, particularly those involved in the infection of a mammalian host. A putative response regulator, Rrp2, ostensibly is required for activation of the RpoN-dependent transcription of rpoS. ...
ORGANISM(S): Borrelia burgdorferi 
2008-09-09 | E-GEOD-11284 | biostudies-arrayexpress
ProteomicsBorrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme community
Lyme disease is a result from an infection by the spirochete Borrelia burgdorferi, and is the leading vector-borne disease in North America. Due to the genomic and proteomic variability of different B. burgdorferi isolates, the study and further comparison of their proteome is key to understand the...
ORGANISM(S): Borrelia sp. tAG21 
2025-05-06 | PXD042072 | Pride
Borrelia burgdorferi Proteomics Mass spectrometry 
TranscriptomicsIdentification of the differences between gene expression in normal human dermal fibroblasts (NHDF cell line) infected with Borrelia burgdorferi sensu lato spirochetes
The similarity of Lyme borreliosis to other diseases and the complex pathogenesis cause diagnostic and therapeutic difficulties. Changes at the cellular and molecular level after Borrelia sp. infection remain still poorly understood. Therefore, the present study focused on the gene expression in hum...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-68741 | biostudies-arrayexpress
TranscriptomicsBorrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi
Our study is the first to demonstrate BadR as a repressor of rpoS and thus facilitates spirocheteM-bM-^@M-^Ys transition back into ticks. BadR binds upstream and represses rpoS in unfed ticks. GLcNA-6P, an abundant nutrient of blood and released by subsequent remodeling of the tick peritrophic memb...
ORGANISM(S): Borrelia burgdorferi B31 
2013-02-22 | E-GEOD-38827 | biostudies-arrayexpress
ProteomicsBorrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme community
Lyme disease is a result from an infection by the spirochete Borrelia burgdorferi, and is the leading vector-borne disease in North America. Due to the genomic and proteomic variability of different B. burgdorferi isolates, the study and further comparison of their proteome is key to understand the...
ORGANISM(S): Borreliella burgdorferi 
2024-09-03 | PXD046281 | Pride
Borrelia burgdorferi Proteomics Mass spectrometry 
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