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TranscriptomicsShort RNAs expression profiling in circulating CD34+ cells from Primary Myelofibrosis patients and from normal controls pooled bone marrow CD34+ cells.
We report the application of Illumina short RNA sequencing for characterization and discovery of miRNAs and moRNAs, and for identification of differentially expressed small RNAs in circulating CD34+ cells from Primary Myelofibrosis (PMF) patients and from normal controls pooled bone marrow CD34+ cel...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-69089 | biostudies-arrayexpress
TranscriptomicsImpact of miRNAs modulation on regulatory networks and pathways involved in colon cancer and metastasis development
Originally linked with development and differentiation, the role of microRNAs (miRNAs) in many important biological processes has emerged and dysregulation of miRNA expression has been connected with cancer pathogenesis. The association between abnormal expression levels of miRNAs and colon cancer...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-35834 | biostudies-arrayexpress
TranscriptomicsLong RNAs expression profiling of 20 Italian Large White pig backfat
We report the application of Illumina RNA sequencing for characterization and discovery of genes and transcripts in Italian Large Whtie pig backfat tissue. RNAs sequencing for long RNA quantification, discovery, characterisation and differential expression evaluation.
ORGANISM(S): Sus scrofa 
2016-03-15 | E-GEOD-68007 | biostudies-arrayexpress
TranscriptomicsShort RNAs expression profiling in SET2 cells.
We report the application of Illumina short RNA sequencing for characterization and discovery of miRNAs and moRNAs in SET2 cells carrying JAK2 V617F mutation. Short RNAs sequencing for miRNA quantification, discovery and characterisation.
ORGANISM(S): Homo sapiens 
2012-02-08 | E-GEOD-30672 | biostudies-arrayexpress
TranscriptomicsInhibition of Jak2 in SET2 cell line with INC424 (two time points and 3 dose levels in triplicate)
SET2 cells were incubated with increasing concentration of INC424/Ruxolitinib for 3-6 h and RNA was purified. Affymetrix Genechip miRNA array 2.0 was used to identify miRNA species showing a differential expression in treated cells compared with control cells. Exponentially growing SET2 cells were c...
ORGANISM(S): Homo sapiens 
2012-02-08 | E-GEOD-33809 | biostudies-arrayexpress
TranscriptomicsIdentification of MicroRNA Expression Patterns and a MicroRNAs/mRNA Regulatory Network in Multiple Myeloma
To date, little evidence of miRNA expression/deregulation in multiple myeloma (MM) has been reported. To characterize miRNA expression profiling of MM plasma cells (PCs) and integrate miRNA expression data with other molecular features of MM patients, global miRNA expression profiles were generated ...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-17498 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [PCL, gene]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-73452 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [PCL, miRNA]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-73454 | biostudies-arrayexpress
TranscriptomicsMouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.
Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress
TranscriptomicsReconstruction of microRNA/genes transcriptional regulatory networks of multiple myeloma through in silico integrative genomics analysis [MM, miRNA]
The identification of deregulated miRNA in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. In the present study, we take virtue of in silico integrative genomics analysis to generate an unprecedented global view of the transcriptional regulatory networks mo...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-70254 | biostudies-arrayexpress
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