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ProteomicsSexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage
Male and female collagen-enriched fraction of cartilage from bovine knees. Full thickness cartilage plugs without subchondral bone were digested with chondroitinase for 24 hours to remove proteoglycans. Cartilage was further decellularized with SDS. LUM1_811145: channels 126, 127, 128 female, chan...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
MSV000092997 | MassIVE
TranscriptomicsBovine cartilage zone arrays
Objective. Identify novel genes and pathways specific to superficial (SZ), middle (MZ) and deep zones (DZ) of normal articular cartilage. Methods. Articular cartilage was obtained from knees of 4 normal human donors. The cartilage zones were dissected on a microtome. RNA was analyzed on human genom...
ORGANISM(S): Bos taurus 
2012-07-31 | E-GEOD-39796 | biostudies-arrayexpress
TranscriptomicsThe temporal transcriptomic signature of cartilage formation
To study chondrogenesis, we used a chicken limb bud model: We used RNA sequencing, and examined the differences between gene expression patterns during cartilage formation in micromass cultures of embryonic limb bud-derived progenitors. We sequenced in triplicate at Day 0,1,2,3,4,6,10,15 and also fr...
ORGANISM(S): Gallus gallus 
2023-03-28 | E-MTAB-12770 | biostudies-arrayexpress
ProteomicsInteraction between bovine IL-1-stimulated cartilage and human serum, LC-MS/MS
Joint diseases are often characterized by inflammatory processes resulting in pathological changes in joint tissues, including cartilage degradation and release of components to the synovial fluid. The complement system plays a central role in promoting the inflammation. Since several cartilage prot...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2016-09-27 | PXD004158 | Pride
Il-1 Bovine cartilage Human serum Lc-ms/ms 
TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
TranscriptomicsHuman cartilage zone arrays
Objective. Identify novel genes and pathways specific to superficial (SZ), middle (MZ) and deep zones (DZ) of normal articular cartilage. Methods. Articular cartilage was obtained from knees of 4 normal human donors. The cartilage zones were dissected on a microtome. RNA was analyzed on human genom...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39795 | biostudies-arrayexpress
ProteomicsProteomic analysis of dexamethasone effects on cartilage breakdown
An in vitro explant culture model of cartilage breakdown (post-traumatic osteoarthritis), where explant media mimics the synovial fluid. The OA model was induced by cytokine treatment with or without injury and potential therapeutic treatment was investigated by adding dexamethasone. Proteins releas...
ORGANISM(S): Bos taurus (Bovine) 
2020-09-14 | PXD020756 | Pride
Proteomics Osteoarthritis Cartilage Explant culture Bovine 
ProteomicsLocal depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understanding of how cartilage repairs minor defects. Here, we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-07-18 | PXD035246 | Pride
Proteoglycan depletion Cartilage repair Catabolic enzyme Tissue engineering 
ProteomicsProfile of growth factors in calf costochondral junction – the site of initial bone formation
Endochondral bone formation is orchestrated by growth factors produced by chondrocytes and deposited in cartilage matrix. Some of these factors were identified, but their complete list and relationship remains unknown. In this work the growth factors were isolated from calcified cartilage of costoch...
ORGANISM(S): Bos taurus (Bovine) 
2021-05-03 | PXD021781 | Pride
Growth factors Calcified cartilage Endochondral bone formation Osteoclasts 
UnknownIn Vitro Analysis of Cartilage Regeneration Using a Collagen Type I Hydrogel (CaReS) in the Bovine Cartilage Punch Model.
Not available
S-EPMC6585298 | biostudies-literature
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