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MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
TranscriptomicsTranscriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology
Background: Weaning of beef calves is a necessary husbandry practice and involves separating the calf from its mother, resulting in numerous stressful events including dietary change, social reorganisation and the cessation of the maternal-offspring bond and is often accompanied by housing. While mu...
ORGANISM(S): Bos taurus 
2012-06-25 | E-GEOD-37447 | biostudies-arrayexpress
ProteomicsBoLA-DRimmunopeptidomics in Theileria parva infected, bovine cell lines
The ability to maintain T.parva-infected cell lines as rapidly proliferating cells in vitro that express high levels of both MHCI and MHCII, makes this a particularly amenable system in which to apply MHCp elution analysis. Furthermore, the ability of T. parva-infected cells to recall antigen-specif...
ORGANISM(S): Bos taurus (Bovine) 
2022-05-19 | PXD024053 | Pride
Immunppeptidomics Bovine leukocyte antigen  theileria parva  mhc 
TranscriptomicsRole of SPI-1 Secreted Effectors, SipA, SopABDE2, in Acute Bovine Response to Salmonella enterica Serovar Typhimurium
Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and calves characterized by diarrhea and polymorphonuclear cell (PMN) influx to the intestinal mucosa. The Salmonella Type III Secretion System encoded at Pathogenicity Island I (SPI-1) translocates the Salmonel...
ORGANISM(S): Bos taurus 
2012-01-10 | E-GEOD-13847 | biostudies-arrayexpress
ProteomicsAnalysis of bovine leukocyte antigen (BoLA)-associated peptides by LC-MS
An increasing amount of MHC presented peptides identified by mass spectrometry (MS ligands) has been published. Handling and interpretation of MS ligand data is in general challenging due to the poly-specificity nature of the data. We here outline a general pipeline for dealing with this challenge,...
ORGANISM(S): Bos taurus (Bovine) 
2017-11-20 | PXD008151 | Pride
Immunopeptidomics Bola 
UnknownBovine Neonatal Pancytopenia-Associated Alloantibodies Recognize Individual Bovine Leukocyte Antigen 1 Alleles.
Not available
S-EPMC6102493 | biostudies-literature
TranscriptomicsTranscription profiling of bovine dendritic cells after infection with virulent or avirulent
rinderpest viruses., measles virus or mock infection
Changes in transcription in bovine dendritic cells after infection with virulent or avirulent
rinderpest viruses., measles virus or mock infection.
ORGANISM(S): Bos taurus 
2009-12-07 | E-MEXP-1856 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
TranscriptomicsMicroRNA regulation of the bovine local and systemic monocyte transcriptional responses to an in vivo Streptococcus uberis challenge
MicroRNA regulation of the bovine local and systemic monocyte transcriptional responses to an in vivo Streptococcus uberis challenge Milk and blood isolated CD14+ monocyte cells taken from 5 infected Holstein friesians and 5 control Holstein friesians. Five animal infected with live S. uberis, cells...
ORGANISM(S): Bos taurus 
2014-07-03 | E-GEOD-51856 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of bovine oocytes with high developmental competence obtained from FSH-stimulated animals
The objective of the study was to analyze the impact of various lenght FSH withdrawal period (coasting) after the last FSH injection on transcriptome changes in in vivo bovine oocytes at the GV stage. Oocytes were collected from super-stimulated animals after 20, 44, 68 and 92 hours of coasting. For...
ORGANISM(S): Bos taurus 
2013-06-21 | E-GEOD-38345 | biostudies-arrayexpress
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