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TranscriptomicsInduction of Senescence in Diterpene Ester-Treated Melanoma Cells via PKC-dependent Hyperactivation of the MAPK Pathway
The diterpene ester PEP005 is a novel anticancer agent that activates PKC and cures subcutaneous murine melanoma by topical application. We now describe the in vitro cytostatic effects of PEP005 and the diterpene ester TPA, observed in 20% of human melanoma cell lines. Primary cultures of normal h...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-3484 | biostudies-arrayexpress
GenomicsOpen chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity [DNase_seq].
The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of di...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-30224 | biostudies-arrayexpress
GenomicsOpen chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity [FAIRE_seq]
The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of di...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-30225 | biostudies-arrayexpress
GenomicsOpen chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity [ChIP_seq].
The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of di...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-30226 | biostudies-arrayexpress
UnknownRandomised clinical trial investigating the specificity of a novel skin test (C-Tb) for diagnosis of M. tuberculosis infection.
Not available
S-EPMC3653866 | biostudies-literature
TranscriptomicsTranscription profiling of human cell lines MCF7, COLO-205 and SK-MEL-5 following treatment with PEP008
We previously identified the induction of growth arrest with phenotypic characteristics of senescence in melanoma cell lines sensitive to diterpene esters, indicating a therapeutic potential. Here we compared the cytostatic effects of two diterpene esters namely TPA (12-O-tetradecanoylphorbol-13-ac...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8742 | biostudies-arrayexpress
UnknownCluster M mycobacteriophages Bongo, PegLeg, and Rey with unusually large repertoires of tRNA isotypes.
Not available
S-EPMC3958112 | biostudies-literature
UnknownDifferences in the genome, methylome, and transcriptome do not differentiate isolates of Streptococcus equi subsp. equi from horses with acute clinical signs from isolates of inapparent carriers.
Not available
S-EPMC8202921 | biostudies-literature
UnknownLabel-free quantitative proteomic analysis of M. longissimus dorsi from cattle during dietary restriction and subsequent compensatory growth.
Not available
S-EPMC7018817 | biostudies-literature
ProteomicsMouse TAPBPR functions as an MHC-I peptide exchange catalyst
Human TAPBPR is known to function as a Major Histocompatibility Complex class I (MHC-I) peptide exchange catalyst which shapes the peptide repertoire presented to immune cells. Never14theless, investigations characterizing TAPBPR from other species are limited. Here, we characterize mouse TAPBPR, ex...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD068540 | Pride
H-2kb Mouse tapbpr Peptide exchange H-2db Mhc-i Calnexin 
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