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TranscriptomicsTranscription profiling of mouse H-2Kb muscle cells treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours
The basic design of the experiment is as described in Fryer et al.(2000)Diabetes 49:1978, and is similar to proto-BAIR (EXP_BAIR_0603_02). H-2Kb muscle cells were treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours.
ORGANISM(S): Mus musculus 
2022-11-23 | E-BAIR-7 | biostudies-arrayexpress
UnknownIdentities of P2 and P3 Residues of H-2Kb-Bound Peptides Determine Mouse Ly49C Recognition.
Not available
S-EPMC4493100 | biostudies-literature
UnknownThe Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and Experimental Study.
Not available
S-EPMC4535769 | biostudies-literature
ProteomicsThe self-peptide repertoire plays a critical role in transplant tolerance induction
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly-alloreactive CD8+ T cells have not been defined. In this study, we used a combination of genetically-engineered MHC I constructs, mice with a hepatocyt...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD023015 | Pride
Immunopeptidomics Hla Transplantation 
ProteomicsThe self-peptide repertoire plays a critical role in transplant tolerance induction
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly-alloreactive CD8+ T cells have not been defined. In this study, we used a combination of genetically-engineered MHC I constructs, mice with a hepatocyt...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD022695 | Pride
Immunopeptidomics Hla Transplantation 
TranscriptomicsTCRb-seq of mouse CD8+ T cells isolated from Cd4-Cre and Ch25hfl/flCd4-Cre mice following VSV-OVA infection
To analyze TCR diversity, CD8+ T cells specific to the OVA (257-264) peptide-H-2Kb tetramers were isolated from Cd4-Cre and Ch25hfl/flCd4-Cre mice following VSV-OVA infection. The KLRG1+CD127– effector cell population was subsequently sorted, and total RNA was extracted from the cell samples using T...
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16000 | biostudies-arrayexpress
TranscriptomicsNeoantigen identification for 1956 and F244 murine MCA-sarcomas
This study was to predict neoantigens in 1956 and F244 murine MCA-sarcomas (female C57BL/6N and male 129S6 lines, respectively). Mutations were called by comparing tumor versus normal whole exome sequencing (WES) data, and filtered for expressing mutations using RNA-seq data. Out of expressing mutat...
ORGANISM(S): Mus musculus 
2024-05-20 | GSE267886 | GEO
ProteomicsReshaping of the MHC-I ligandome in response to reovirus-based cancer immunotherapy
Oncolytic viruses (OVs), known for their cancer-killing characteristics, overturn tumor-associated defects in antigen presentation through the MHC class I pathway and induce protective neo antitumor CD8 T cell responses. Nonetheless, whether OVs shape the tumor MHC-I ligandome remains unknown. Here,...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013066 | Pride
Antitumor immunity Reovirus Mhc ligandome Mass spectrometry Cancer immunotherapy Cd8 t cell epitopes Oncolytic virus 
UnknownDominant role of the α-chain in rejection of tumor cells bearing a specific alloantigen in TCRα transgenic mice and in in vitro experiments.
Not available
S-EPMC6690675 | biostudies-literature
UnknownDynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
Not available
S-EPMC8138769 | biostudies-literature
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