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GenomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [mRRBS]
Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. We found that pregnancy had the most significant effects on stem cells, inducing a distinct epigenetic state that remained stable through life. Mammary glands were collected from mice at non...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54149 | biostudies-arrayexpress
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
GenomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54150 | biostudies-arrayexpress
TranscriptomicsPSY3642_to_PSY3639_SC_aerobic
We designed and experimentally validated an in silico gene deletion strategy for engineering endogenous one-carbon (C1) metabolism in yeast. Specifically, a Flux Balance Analysis (FBA) model predicted that five genes ALT2, FDH1, FDH2, FUM1, and ZWF1, when deleted in combination, would cause Sacchar...
ORGANISM(S): Saccharomyces cerevisiae 
2009-07-24 | E-GEOD-12240 | biostudies-arrayexpress
ProteomicsExtracellular Matrix Protein 1 as a critical mediator of inflammation-to-fibrosis crosstalk in wound healing after myocardial infarction
Aims and introduction: Cardiac fibrosis is the hallmark of cardiac disease, particularly myocardial infarction (MI), and is one of the most prevalent causes of heart failure. MI is intricately linked to inflammation, extracellular matrix (ECM) remodelling, and cardiac fibrosis, however the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027626 | Pride
Ecm1 Adult human cardiac fibroblast (hucfb) cell line Human Cardiac wound healing Extracellular matrix Heart failure (hf) 
TranscriptomicsSynthetic circuits for tracking human cell fate
Cells respond heterogeneously to DNA damage. We engineered genetic circuits to detect differential responses in a population that persist for many days post-stimulus. We used microarrays to compare memory and non-memory subpopulations 3 days after DNA damage or doxycycline exposure. MD12/p53R2-RE an...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-38189 | biostudies-arrayexpress
TranscriptomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [reproductive stages]
Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. We found that pregnancy had the most significant effects on stem cells, inducing a distinct epigenetic state that remained stable through life. Mammary glands were collected from different r...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54147 | biostudies-arrayexpress
TranscriptomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [inhibitor study]
Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. To explore the role of DNA methylation in luminal cell differentiation and pregnancy-induced changes, we determined the genome-wide DNA methylation and gene expression profiles of mammary ep...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54148 | biostudies-arrayexpress
UnknownLandiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial.
Not available
S-EPMC10600724 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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