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TranscriptomicsTranscription profiling of human HUVEC cells exposed for 2, 4, 8 and 24 hours to (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate) 250 uM
A time-course experiment was performed: HUVECs were exposed for 2, 4, 8 and 24 hours to (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate) 250 uM.
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-8 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC cells exposed to 1 mM sodium nitroprusside (SNP) for 2, 4, 8 and 24 hours vs untreated control cells
HUVEC were exposed to 1 mM sodium nitroprusside (SNP) for 2, 4, 8 and 24 hours and compared to untreated control cells.
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-6 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC cells exposed to 0.1, 1 and 10 mM sodium nitroprusside (SNP) for 4 hours vs untreated control cells
HUVEC were exposed to 0.1, 1 and 10 mM sodium nitroprusside (SNP) for 4 hours and compared to untreated control cells.
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-5 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC cells exposed to 250 uM DETA-NONOate for 4 hours in the presence and absence of 10 uM of the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ)
HUVECs were exposed to 250 uM DETA-NONOate for 4 hours in the presence and absence of 10 uM of the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ). Control cells were exposed to vehicle (methanol 0.1%).
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-7 | biostudies-arrayexpress
TranscriptomicsControl over Control
Control samples of HUVEC were obtained parallel with a 4 hr experiment and compared to control.
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-9 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to injury in kidney cortex of nitric oxide depleted rats are ameliorated by vitamin E
Male Sprague-Dawley rats were given NOS inhibitor L-NNA (500 mg/l water) for 4 days, 21 days or 21 days with Vitamin E in chow (0.7 g/kg BW/day) (4d-LNNA, 21d-LNNA and 21d-LNNA+VitE, respectively).
ORGANISM(S): Rattus norvegicus 
2007-03-01 | E-UMCU-18 | biostudies-arrayexpress
TranscriptomicsEffect of two weeks erythropoietin treatment on monocyte transcriptomes of cardiorenal patients
Patients with combined heart and renal failure, also termed the cardiorenal syndrome (CRS), have high cardiovascular morbidity and mortality. Several key connectors between heart and kidney have been recognized, such as oxidative stress, inflammation, the renin-angiotensin system and the sympatheti...
ORGANISM(S): Homo sapiens 
2009-08-11 | E-GEOD-17582 | biostudies-arrayexpress
TranscriptomicsFlow in the presence or absence of L-NAME or ODQ versus no flow
HUVEC were exposed to 150 minutes of high shear stress using a Cellmax flow cardtridge either in the presence or absence of 100 uM L-NAME or 10 uM L-ODQ; luminal flow was 25 ml/min; resulting a shear stress of 25 dyn/cm2. A simultaneously run cartridge not subjected to luminal, but to pericapillary ...
ORGANISM(S): Homo sapiens 
2007-04-25 | E-UMCU-10 | biostudies-arrayexpress
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