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GenomicsAutozygosity pilot Born in Bradford
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAS00001000462 | EGA
GenomicsEGAS00001000462-sc-20141120 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001001079 | EGA
GenomicsEGAS00001000462-sc-20170511 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001003329 | EGA
TranscriptomicsTranscription profiling by array of mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice) against wild type controls to study the role of PGC1beta in metabolism
PGC1beta is a transcriptional coactivator that potently stimulates mitochondrial biogenesis and respiration of cells. Here, we have generated mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice). These mice express a mutant protein that has reduced coactivation activity on a su...
ORGANISM(S): Mus musculus 
2009-04-24 | E-GEOD-6210 | biostudies-arrayexpress
ProteomicsAn Isocaloric High-Fat Diet Improves Lifespan in Rats and Drosophila
The health effect of dietary fat has been one of the most vexing issues in the nutrition field. Few animal studies have examined the impact of high-fat diets on lifespan by controlling energy intake. In this study, we found that compared to a normal diet, an isocaloric high-fat diet (IHF) significan...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-06 | PXD022585 | Pride
Isocaloric High-fat diet Proteomics Lifespan 
ProteomicsA-to-I mRNA editing enables bacteria to produce two protein versions from a single gene and affects bacterial growth
Adenosine-to-inosine (A-to-I) mRNA editing can affect the sequence and function of translated proteins because the ribosome reads inosine (I) as guanosine (G). Previously, we discovered that A-to-I mRNA editing occurs in Escherichia coli. However, the prevalence of A-to-I mRNA editing across bacteri...
ORGANISM(S): Acinetobacter baylyi 
2025-07-21 | PXD051887 | Pride
Adenosine-to-inosine (a-to-i) mrna editing  gammaproteobacteria 
UnknownPhenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Not available
S-EPMC6820948 | biostudies-literature
UnknownPerspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
Not available
S-EPMC5916814 | biostudies-literature
UnknownGenomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.
Not available
S-EPMC6002769 | biostudies-literature
UnknownAcute Cardiac Care 2012
Not available
S-EPMC3760571 | biostudies-literature
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