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GenomicsChromatin Profiling by Directly Sequencing Small Quantities of Immunoprecipitated DNA
Chromatin structure and transcription factor localization can be assayed genome-wide by sequencing genomic DNA fractionated by protein occupancy or other properties. However, current technologies involve multiple steps that introduce bias and inefficiency. Here we apply a single-molecule approach to...
ORGANISM(S): Mus musculus 
2009-11-29 | E-GEOD-18699 | biostudies-arrayexpress
TranscriptomicsArgonaute2 mediates compensatory expansion of the pancreatic M-CM-^_-cell
Pancreatic M-CM-^_-cells adapt to compensate for the increased metabolic demand during insulin resistance. While the microRNA pathway has an essential role in the expansion of M-CM-^_-cell mass, the extent of its contribution is unclear. Here we show that miR-184 is silenced in the pancreatic islets...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-46623 | biostudies-arrayexpress
UnknownMyeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice.
Not available
S-EPMC8468863 | biostudies-literature
TranscriptomicsDNA_library hybridization
PCR read-off microarrays: The ability to efficiently and economically generate libraries of defined pieces of DNA would have a myriad of applications, not least in the area of defined or directed sequencing and synthetic biology, such as protein engineering and aptamer library screening, but also in...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-MEXP-3099 | biostudies-arrayexpress
GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
TranscriptomicsAtopic Eczema expression profiling, Saaf_2008
Background: Atopic eczema (AE) is a common chronic inflammatory skin disorder. In order to dissect the genetic background several linkage and genetic association studies have been performed. Yet very little is known about specific genes involved in this complex skin disease, and the underlying molec...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12511 | biostudies-arrayexpress
UnknownFiona Bradley
Not available
S-EPMC1125619 | biostudies-literature
UnknownOncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
Not available
S-EPMC8530981 | biostudies-literature
UnknownComparative genome and phylogenetic analysis revealed the complex mitochondrial genome and phylogenetic position of Conopomorpha sinensis Bradley.
Not available
S-EPMC10042987 | biostudies-literature
ProteomicsOct4-FTAP - An expanded Oct4 interaction network: implications for stem cell biology, development, and disease
Control one-step purification
ORGANISM(S): Mus musculus (Mouse) 
2010-04-29 | PRD000216 | Pride
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