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MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
TranscriptomicsRNA-seq of brain mural cells and microvascular fragments
Purpose: Pericytes, the mural cells of blood microvessels, have come into focus as regulators of microvascular development and function, but due to paucity of defining markers, the identification and functional characterization of PC remain problematic, and reported data are often controversial. Her...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-75668 | biostudies-arrayexpress
ProteomicsAge-dependent changes in phosphorylation of signaling molecules in brain tissues of Alzheimer's disease (AD) model mice
To demonstrate the utility of the newly developed dendron-coated phosphokinase antibody array(DPA) in which the antibodies are immobilized on a dendron-coated glass slide, the phosphorylation profiles of brain tissue samples obtained from Alzheimer's disease (AD) model mice were generated. The phosp...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-55452 | biostudies-arrayexpress
ProteomicsB-Cell-based Therapy Controls Glioblastoma Growth by Producing Antibodies that Inhibit Tumor Invasion and Migration
Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor with limited therapeutic options and poor prognosis. Despite current treatments, the invasive nature of GBM often leads to recurrence. A promising alternative strategy is to harness the immune system's potential against t...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-09-10 | PXD046712 | Pride
Glioblastoma multiforme (gbm)  b-cell-based vaccine (bvax)  tumor-reactive antibodies  immunoproteomics 
TranscriptomicsTranscriptome-wide discovery of microRNA binding sites in human brain by Ago2 HITS-CLIP [Ago2-miRNA complexes]
Here, seeking to gain insight into the array of transcripts engaged with miRNAs in human brain, we performed HITS-CLIP to profile transcriptome-wide Ago2:RNA interactions in a panel of eleven post-mortem adult human brain samples harvested from adult motor cortex and cingulate gyrus, regions associa...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-52083 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide discovery of microRNA binding sites in human brain by Ago2 HITS-CLIP [Ago2-miRNA-target mRNA complexes]
Here, seeking to gain insight into the array of transcripts engaged with miRNAs in human brain, we performed HITS-CLIP to profile transcriptome-wide Ago2:RNA interactions in a panel of eleven post-mortem adult human brain samples harvested from adult motor cortex and cingulate gyrus, regions associa...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-52082 | biostudies-arrayexpress
Transcriptomicsm6A mapping in mouse RNA (mouse liver and human brain)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing Identification of m6A modified sequences in mouse liver and human brain
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37004 | biostudies-arrayexpress
UnknownIncreasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Not available
S-EPMC11783731 | biostudies-literature
ProteomicsC-Man peptide pulldowns from Brain
Peptide pulldowns with C-man antibodies to demostrate the utelity of reagents for proteomic analysis. Using Murine brain samples Novel C-man sites are readily identifiable.
ORGANISM(S): Mus musculus (Mouse) 
2020-11-16 | PXD020336 | Pride
C-man Affinity pulldowns Glycopeptides 
TranscriptomicsMouse ischemic tolerance genomic analysis of the brain and blood.
Ischemic tolerance can be induced by numerous preconditioning stimuli, including various Toll-like receptor (TLR) ligands. We have shown previously that systemic administration of the TLR4 ligand, lipopolysaccharide (LPS) or the TLR9 ligand, unmethylated CpG ODNs prior to transient brain ischemia in...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-32529 | biostudies-arrayexpress
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