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MetabolomicsMultiple omics reveal link between the microbiota-gut-brain axis and intracranial aneurysm rupture

Intracranial aneurysms (IAs) are benign cerebrovascular maladies characterized by pathological dilatation in the walls of intracranial arteries. However, spontaneous subarachnoid hemorrhage (SAH) resulting from aneurysm rupture poses a grave threat to the patient's life. Accumulating evidence imp...

2024-12-13 | MTBLS10263 | MetaboLights
ProteomicsHuman and mouse brain, and human cerebrospinal fluid extracellular vesicles LC-MSMS
Extracellular vesicles (EVs) are a unified terminology of membrane-enclosed vesicular species ubiquitously secreted by almost every cell type and present in all body fluids. They carry a cargo of lipids, metabolites, nucleic acids and proteins for their clearance from cells as well as for cell-to-ce...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-02-17 | PXD017273 | Pride
Human Cerebrospinal fluid Lc-msms Extracellular vesicles Brain tissue Mouse Tmt label 
TranscriptomicsEffect of microgravity on brain gene expression in mice
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an elimination of normal head-to-foot hydrostatic pressure gradients. To assess brain gene profile changes ass...
ORGANISM(S): Mus musculus 
2008-08-07 | E-GEOD-12312 | biostudies-arrayexpress
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
ProteomicsDeep Dive in the Proteome of Human Cerebrospinal Fluid: A Valuable Data Resource for Biomarker Discovery and Missing Protein Identification
Cerebrospinal fluid (CSF) is a body fluid of choice for biomarker studies of brain disorders but remains relatively under-studied compared to other biological fluids such as plasma, partly due to the more invasive means of its sample collection. The present study establishes an in-depth CSF proteome...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083965 | MassIVE
GenomicsCharacterization of T cell tumor infiltration in brain metastases through the analysis of the cerebrospinal fluid
Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction of patients with brain metastasis benefit from the treatment with immune checkpoint inhibitors (ICI) and tumor inflammation has been used as a biomarker to predict response. However, the anatomical location o...
EGAS00001004751 | EGA
ProteomicsGFAP and MBP peptides in Traumatic Brain Injury
Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells and is upregulated in astrogliosis following traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown p...
ORGANISM(S): Homo Sapiens 
PXD026550 | panorama
UnknownAdvances in brain barriers and brain fluid research and news from Fluids and Barriers of the CNS.
Not available
S-EPMC4731978 | biostudies-literature
ProteomicsMRM for validation of Brain tumor biomarkers
The emergence of omics technologies over the last decade has helped in advancement of research and our understanding of complex diseases like brain cancers. However, barring genomics, no other omics technology has been able to find utility in clinical settings. The recent advancements in mass spectr...
ORGANISM(S): Homo Sapiens 
2021-06-15 | PXD024238 | panorama
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