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MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
MetabolomicsEffects of a Compound from the Group of Substituted Thiadiazines with Hypothermia Inducing Properties on Brain Metabolism in Rats, a Study In Vivo and In Vitro
The aim of the present study was to examine how administration of a compound of 1,3,4-thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (L-17) with hypothermia inducing properties affects the brain metabolism. The mechanism by which L-17 induces hypothermia is unknown; it may...
2018-07-27 | MTBLS482 | MetaboLights
ProteomicsStable isotope-resolved metabolomics reveals the abnormal brain glucose catabolism in depression based on chronic unpredictable mild stress rats
The severe harm of depression to human life has attracted great attention to neurologists, but its pathogenesis is extremely complicated and has not yet been fully elaborated. Here, we provided a new strategy for revealing the specific pathways of abnormal brain glucose catabolism in depression, whi...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-10 | PXD025548 | Pride
Stable isotope-resolved metabolomics Brain glucose catabolism Depression Liquid chromatography-mass spectrometry Mitochondrial structure and function 
MetabolomicsIn Vitro 1H NMR Metabolic Profiles of Liver, Brain, and Serum in Rats After Chronic Consumption of Alcohol

The impact of alcohol on the body can be investigated with NMR spectroscopy in vitro, which can detect a wide range of metabolites but preparing samples includes tissue biopsy. Blood sampling is less invasive, but blood metabolic content might not reflect the changes occurring in other t...

2023-02-20 | MTBLS453 | MetaboLights
MetabolomicsInduction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer

Tumor-initiating cells (TICs) tend to reside in poorly vascularized regions of tumors and are subjected to nutrient stress. How TICs activate metabolic plasticity for adapting to periods of low nutrient availability, especially during glucose-limiting conditions, has remained unclarified. Here, w...

2025-09-29 | MTBLS8430 | MetaboLights
MetabolomicsLocal and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy
Cerebral ischemia and aging induce local and systemic effects, and impact severity of stroke outcome. We performed comprehensive metabolic profiling to detect metabolites in brain, plasma, and liver as a function of aging and ischemia/reperfusion (IR). Ischemic stroke was induced by middle cerebral ...
2019-02-01 | MTBLS516 | MetaboLights
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Brain tissue metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-12-05 | MTBLS4894 | MetaboLights
TranscriptomicsTranscriptomic effects of GLUT2 knock-down in zebrafish embryos
Glucose transporter 2 (GLUT2) is a key player in the regulation of glucose dynamics in organs central to metabolism, namely the liver, pancreas and intestine In humans, mutations of the GLUT2 gene (Fanconi-Bickel syndrome) cause important defects in glucose homeostasis. Although GLUT2 has been studi...
ORGANISM(S): Danio rerio 
2014-12-23 | E-GEOD-57836 | biostudies-arrayexpress
TranscriptomicsTranscription analysis of E. coli processed at persistent and decreasing glucose limitation in a fed-batch cultivation
A time series of whole-genome transcription profiling of E. coli K-12 W3110 was performed to study the dynamic physiological response of E. coli K-12 W3110 to limited carbon conditions. cDNA from eight time intervals after glucose limitation, representing different stages of glucose depletion, along...
ORGANISM(S): Escherichia coli W3110 
2010-05-19 | E-GEOD-10307 | biostudies-arrayexpress
TranscriptomicsAssessment of CcpA-mediated catabolite control of metabolism and enterotoxin production in Bacillus cereus ATCC 14579
In Bacillus cereus the catabolite control protein CcpA was shown to be involved in optimizing the efficiency of glucose catabolism by activating genes encoding glycolytic enzymes including a non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase that mediates conversion of D-glyceraldehyde 3-p...
ORGANISM(S): Bacillus cereus ATCC 14579 
2010-05-25 | E-GEOD-7843 | biostudies-arrayexpress
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