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MetabolomicsMicroglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights
MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
TranscriptomicsMicroglia in ischemic brain injury
Microglia are resident CNS immune cells that are active sensors in healthy brain and versatile effectors under pathological conditions. Cerebral ischemia induces a robust neuroinflammatory response that includes marked changes in the gene expression and phenotypic profile of a variety of endogenous ...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-18602 | biostudies-arrayexpress
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
MetabolomicsRepair-Associated Macrophages Increase after Early-phase Microglia Attenuation to Promote Ischemic Stroke Recovery

Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 ...

2025-02-20 | MTBLS12240 | MetaboLights
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
TranscriptomicsInterleukin-1 signaling is involved in local self-renewal and maintenance of microglia
During early embryogenesis microglia arise from yolk sac progenitors populating the developing CNS, where they are maintained as tissue-resident macrophages throughout the organism’s lifespan. Here, we describe an experimental system that allows the specific conditional ablation of microglia in vivo...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-68376 | biostudies-arrayexpress
TranscriptomicsExpression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain
Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are ...
ORGANISM(S): Rattus norvegicus 
2011-06-11 | E-GEOD-29885 | biostudies-arrayexpress
TranscriptomicsDefining the microglia transcriptome in multifunctional protein-2 deficient mice
Purpose: We purified whole brain microglia of MFP2 knockout mice and control mice utilizing percoll gradient and FACS sorting, followed by microarray analysis to define the molecular changes in MFP2 knockout mice at the endstage of the disease. We compared the microglia transcriptome of Mfp2-/- micr...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-66420 | biostudies-arrayexpress
MetabolomicsIncreased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To achieve this goal, we compared the brain metabolomes of ipsilateral and contralateral hemispheres from aged male mice u...
2022-10-06 | MTBLS5543 | MetaboLights
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