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ProteomicsAnalysis of N-Glycosylation for SARS-CoV-2 expressed receptor-binding domain VOCs and membrane protein with LC-MS.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human cells by first attaching to the ACE-2 receptor via its receptor-binding domain (RBD) in the spike protein. We investigated the influence of N-glycosylation sites of the RBD and the membrane (M) protein on IgG antibody bind...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
PXD048930 | panorama
ProteomicsCSF glycoproteomics reveals brain-specific changes in glyco-sylation in congenital disorders of glycosylation
In this project, CSF samples from healthy volunteers and patients diagnosed with congenital disorders of glycosylation (CDG) were analyzed with MS-based glycoproteomics to characterize the glycoproteome in the two cohorts. In order to identify highly truncated glycopeptides and glycopeptides that sh...
ORGANISM(S): Homo sapiens (Human) 
2023-01-18 | PXD038787 | Pride
Glycoproteomics Brain-type glycosylation Csf 
ProteomicsMultilayered N-glycoproteome Profiling Reveals Highly Heterogeneous and Dysregulated Protein N-glycosylations Related to Alzheimer’s Disease
Protein N-glycosylation is ubiquitous in brain and closely related to cognition and memory. Alzheimer's disease (AD) is a multifactorial disorder that lacks clear pathogenesis and treatment. Aberrant N-glycosylation has been suggested to be involved in AD pathology. While the systematic variations o...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-25 | PXD015335 | Pride
Glycoproteomics alzheimer's disease 
ProteomicsO-linked Glycosylation of the SARS-CoV-2 Spike is Suppressed by Quaternary Structural Restraints
Understanding the glycosylation of envelope spike (S) protein of SARS-CoV-2 is important in defining the antigenic surface of this key viral target. However, the underlying protein architecture may significantly influence glycan occupancy and processing. There is, therefore, potential for different ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-28 | MSV000087897 | MassIVE
TranscriptomicsElucidating mechanisms by which regulated expression of proteoglycans and glycosylation-related genes in the striatum contribute to Huntington disease
This laboratory focuses on the molecular mechanisms of neuropsychiatric and neurodegenerative disorders Our goal is to elucidate mechanisms by which regulated expression of proteoglycans and glycosylation-related genes contribute to neurodegenerative diseases involving the striatum. A number of stud...
ORGANISM(S): Mus musculus 
2011-03-02 | E-GEOD-27588 | biostudies-arrayexpress
UnknownGlycoproteomics in Cerebrospinal Fluid Reveals Brain-Specific Glycosylation Changes.
Not available
S-EPMC9916115 | biostudies-literature
UnknownGlycosylation as a regulator of site-specific metastasis.
Not available
S-EPMC8930623 | biostudies-literature
UnknownMechanisms of disease: congenital muscular dystrophies-glycosylation takes center stage.
Not available
S-EPMC2855642 | biostudies-literature
UnknownGlycosylation of the sodium channel β4 subunit is developmentally regulated and involves in neuritic degeneration.
Not available
S-EPMC3341604 | biostudies-literature
TranscriptomicsScreening RNA from human uninfected macrophages, activated macrophages and T cells
The Fox laboratory studies the SIV infection of rhesus monkeys as a model for HIV/AIDS, focusing on central nervous system infection, immunity, and brain dysfunction that develops following infection. Previous Fox lab data shows that virions derived from macrophages and T-cells differ in infectivity...
ORGANISM(S): Homo sapiens 
2011-04-29 | E-GEOD-28928 | biostudies-arrayexpress
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