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ProteomicsMultimodal measurement of the transcriptome and proteome in G2/M arrested single cells using nanoSPLITS
Single-cell proteomic data from RO-3306 treated alveolar type II epithelial cells (C10) and untreated C10 cells. Cells were sorted using cellenONE onto several nanoSPLITS chips. Cell lysates were then split for parallel RNAseq and proteomic analysis. For proteomics recovery experiment where both chi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-02 | MSV000090828 | MassIVE
ProteomicsDevelopment of a Robust Score and False Discovery Rate for Metabolite Identification
We used machine learning (ML) to improve metabolite identification confidence in GC-MS data. This project was funded by PNNL's M/Q initiative. All data was collected on an Agilent GC 7890A coupled with a single quadrupole MSD 5975C. Metabolites were derivatized prior to analysis.
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) Aspergillus (ncbitaxon:5052) Homo Sapiens (ncbitaxon:9606) Aspergillus Nidulans (ncbitaxon:162425) 
2022-07-20 | MSV000089933 | MassIVE
MetabolomicsGNPS - Development of a Robust Score and False Discovery Rate for Metabolite Identification
We used machine learning (ML) to improve metabolite identification confidence in GC-MS data. This project was funded by PNNL's M/Q initiative. All data was collected on an Agilent GC 7890A coupled with a single quadrupole MSD 5975C. Metabolites were derivatized prior to analysis.
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) Aspergillus (ncbitaxon:5052) Homo Sapiens (ncbitaxon:9606) Aspergillus Nidulans (ncbitaxon:162425) 
2022-07-20 | MSV000089933 | GNPS
ProteomicsMultimodal measurement of the transcriptome and proteome from dissociated human pancreatic islet cells using nanoSPLITS
Human pancreatic islets from two human donors (Prodo Laboratories) were acquired and cultured for 24 hr in pancreatic islet media (PIMS, Prodo Laboratories). Single cells were dissociated with TrypLE for ~15-30 minutes, washed with PBS, stained with Calcein-AM/propidium iodide, and sorted onto nanoS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-07 | MSV000093330 | MassIVE
MetabolomicsTrans-tissue molecular coordination in high-intensity physical activity
High-intensity physical activity has major impacts in different parts of the body. However, the regulatory coordination between different tissues to support the high physical demands is poorly understood. Here we performed a multi-omics analysis of blood plasma, urine and saliva from a group of fire...
2025-07-03 | MTBLS1891 | MetaboLights
ProteomicsCharactering the lipidome of Huh7 Zika infected cells at 24hpi and 48hpi
Lipidomic analysis of Huh7 cells infected with Zika FSS13025 at an MOI of ~10. Samples collected at 24 and 48 hrs post infection.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-29 | MSV000083079 | MassIVE
ProteomicsRelative complement deficiency predicts development of islet autoimmunity and type 1 diabetes
Complement proteins were measured using selected reaction monitoring (SRM)-based targeted proteomics.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-06 | MSV000090848 | MassIVE
ProteomicsSpatially resolved top-down proteomics of tissue sections based on a microfluidic nanodroplet sample preparation platform
We demonstrate spatially resolved top-down proteomics (TDP) for proteoform identification and quantification from small sections of rat brain. We used the nanoPOTS (nanodroplet Processing in One pot for Trace Samples) platform, further improving the sample preparation by adding benzonase in the extr...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606) 
2022-03-30 | MSV000089163 | MassIVE
MetabolomicsGNPS - Obesity and GDM associated changes in placental and maternal blood lipidomic profile: evidence for sexual dimorphism
This study assesses fatty acid composition of lipids in matched maternal plasma and placental tissue from lean, obese and gestational diabetes (GDM) women stratified by fetal sex. Obesity and GDM are associated with adverse pregnancy outcomes and program the offspring for cardiometabolic disease in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-09 | MSV000094962 | GNPS
MetabolomicsGNPS - Human blood plasma circadian lipidome misalignment due to night shift simulation
Blood plasma was collected from a total of 14 subjects participating in a between-groups, in-laboratory study. Healthy volunteers (ages 22-34, BMI average 25.7) were assigned to a 3 day simulated night-shift schedule (6 male, 1 female) or a simulated day-shift (i.e., control, 4 male, 3 female) sched...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086152 | GNPS
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