Branched-chain ketoacids

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Unknown (36)
Proteomics (4)
Metabolomics (4)
Genomics (1)

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environmental samples (1)
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Coronavirus PREDICT CoV-19 (1)
Shigella flexneri 5a str. M90T (1)
Ginglymostoma cirratum (1)
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Cellulomonas sp. B6 (1)
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Amphibia (1)
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Mammuthus (1)
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Deltacoronavirus PDCoV/USA/Illinois121/2014 (1)
Mycobacterium avium 104 (1)

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MassIVE (3)
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pride (1)
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Tissue

Heart (2)
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Macrophage (1)

Disease

Obesity (2)

Technology Type

Mass Spectrometry (3)
Mass spectrometry (2)
EI (2)
Shotgun proteomics (1)

Instrument Platform

Liquid Chromatography MS - positive - reverse phase (2)
Thermo Exploris 480 (1)
Orbitrap Exploris 480 (1)
Q Exactive Plus (1)
Gas Chromatography MS - (1)
Gas Chromatography MS - positive (1)

Publication Date

2022 (3)
2025 (1)
2023 (1)

CHEBI ID

CHEBI:18133 (2)
CHEBI:18186 (2)
CHEBI:30838 (2)
CHEBI:16811 (2)
CHEBI:24898 (2)
CHEBI:15356 (2)
CHEBI:27266 (2)
CHEBI:17822 (2)
CHEBI:16199 (2)
CHEBI:26271 (2)
CHEBI:28044 (2)
CHEBI:16708 (2)
CHEBI:17148 (2)
CHEBI:42111 (2)
CHEBI:16737 (2)
CHEBI:15891 (2)
CHEBI:27897 (2)
CHEBI:17050 (2)
CHEBI:16113 (2)
CHEBI:15428 (2)
CHEBI:25094 (2)
CHEBI:18257 (2)
CHEBI:16958 (2)
CHEBI:15741 (2)
CHEBI:32816 (2)
CHEBI:6650 (2)
CHEBI:25017 (2)
CHEBI:15978 (2)
CHEBI:28300 (2)
CHEBI:18012 (2)

Metabolite Name

Beta alanine (2)
Glycerol-3-phosphate (2)
Pyruvic acid (2)
Urea (2)
Hexose (2)
Lactic acid (2)
Cholesterol (2)
Citric acid (2)
Tyrosine (2)
Serine (2)
Phenylalanine (2)
Creatinine (2)
3-phosphoglycerate (2)
Methionine (2)
Valine (2)
Putrescine (2)
Proline (2)
Malic acid (2)
Lysine (2)
Isoleucine (2)
Leucine (2)
Glycine (2)
Glutamine (2)
Cysteine (2)
Alanine (2)
Taurine (2)
Fumaric acid (2)
Succinic acid (2)
Adenine (2)
Itaconic acid (2)

First Public Date

2026 (1)

Release Date

2024 (8)
2023 (6)
2021 (5)
2025 (3)
2022 (3)
2019 (2)
2017 (2)
2026 (1)
2020 (1)
2016 (1)
2014 (1)
2011 (1)
2009 (1)
2001 (1)

Lab affiliation

Head of Molecular Systems Biology Lab (MOSYS), Vice-Head Department Functional & Evolutionary Ecology, Head of Large Instrument Facility for Mass Spectrometry in Life Sciences, Chair of the Vienna Metabolomics Center (VIME) (1)

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Branched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights

Branched-chain alpha-ketoacids are preferentially reaminated and activate protein synthesis in the mouse heart

Not available

ORGANISM(S): Mus musculus

ST001666 | MetabolomicsWorkbench

Branched-chain alpha-ketoacids are preferentially reaminated and activate protein synthesis in the rat heart

Not available

ORGANISM(S): Rattus norvegicus

ST001665 | MetabolomicsWorkbench

Cancer-derived branched-chain ketoacids modulate macrophage polarization and metabolic reprogramming

This study aims to uncover the effects of cancer-derived branched-chain ketoacids on macrophage polarization and the underlying mechanism. We uncovered the global responses of branched-chain ketoacids-stimulated macrophages by proteomics analysis. Functional enrihment analysis indicated that these k...

ORGANISM(S): Mus musculus (Mouse)

2022-10-04 | PXD032100 | Pride