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ProteomicsSMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover
Structural maintenance of chromosomes (SMC) complexes, cohesin, condensin and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all three SMC complexes and are ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-05 | PXD022717 | Pride
Condensin Sumo chains Smc5/6 Senp/ulp proteases Cohesin Smc complexes Sumo Slx5/8 Pds5 Stubl-mediated proteasomal degradation 
TranscriptomicsEssential Roles of the Smc5/6 complex in Replication through Pausing Sites and Endogenous DNA Damage Tolerance
The essential functions of the conserved Smc5/6 complex remain elusive. To uncover its roles in genome maintenance, we established Saccharomyces cerevisiae cell cycle-regulated alleles that enable restriction of Smc5/6 components to S or G2/M. Unexpectedly, the essential functions of Smc5/6 segregat...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-19 | E-GEOD-72241 | biostudies-arrayexpress
TranscriptomicsMultifaceted down-regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes local recombination at sites of stalled replication
The SUMO-like domains-containing family of proteins to which Saccharomyces cerevisiae Esc2 belongs facilitates DNA damage tolerance (DDT) via elusive mechanisms. Here we report that Esc2 promotes recombination-mediated DDT by engaging in functional and physical interactions with Srs2 and Elg1, two r...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-16 | E-GEOD-65701 | biostudies-arrayexpress
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