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ProteomicsEndothelial cell proteomic response to Rickettsia conorii infection
Rickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging disease with significant mortality. This obligate, gram-negative intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leakage. In the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080856 | MassIVE
ProteomicsEndothelial cell proteomic response to Rickettsia conorii infection
Rickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging disease with significant mortality. This obligate, gram-negative intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leakage. In the ...
ORGANISM(S): Homo sapiens (Human) 
2015-11-17 | PXD002650 | Pride
Endothelial cell Rickettsia conorii Lc-ms/ms 
ProteomicsSegmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma
Asthma is a complex syndrome associated with episodic decompensations provoked by aeroaller-gen exposures. The underlying pathophysiological states driving exacerbations are latent in the resting state and do not adequately inform biomarker-driven therapy. A better understanding of the pathophysiolo...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033172 | Pride
Allergic asthma  saturated fatty acid synthesis  segmental bronchial antigen provocation  metabolomics  phenotype 
ProteomicsDiscovery of RSV-induced BRD4 protein interactions using native immunoprecipitation and parallel accumulation – serial fragmentation (PASEF) mass spectrometry
Respiratory Syncytial Virus (RSV) causes severe inflammation and airway pathology in children and the elderly by infecting the epithelial cells of the upper and lower respiratory tract. RSV replication is sensed by intracellular pattern recognition receptors upstream of the IRF and NF-$\upkappa$B tr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-17 | PXD023983 | Pride
Human Ap-ms Brd4 Lung Rsv 
ProteomicsStructural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes an extensively glycosylated surface spike (S) protein to mediate host cell entry and the S protein glycosylation plays key roles in altering viral binding/function and infectivity. However, the molecular structures and glycan hete...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-27 | MSV000087891 | MassIVE
ProteomicsSystematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights Into Pathogenesis Of RSV-Induced Lower Respiratory Tract Infections
Lower respiratory tract infections (LRTI) from human Respiratory Syncytial Virus (RSV) are a significant cause of morbidity in children. A component of LRTI pathogenesis is due to signals generated by infected lower airway cells that alter lymphocyte populations and trigger airway remodeling. To ob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080867 | MassIVE
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