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MetabolomicsStreptococcus anginosus promotes hepatocellular carcinoma progression and BET inhibitor resistance by inducing BRD4 lactylation

Hepatocellular carcinoma (HCC) is a highly aggressive form of carcinoma with a poor prognosis. Diagnostic markers and potential therapeutic targets for HCC are urgently needed. Here, we demonstrate that fecal microbiota transplantation (FMT) using stool samples from HCC patients significantly pro...

2025-12-05 | MTBLS12398 | MetaboLights
Proteomics: Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular details of BRD4 regulation remain largely unknown. Here, we report that PRMT2- and PRMT4-med...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD034650 | Pride
Transcription Dna repair Arginine methylation Prmt2/4 Brd4 
ProteomicsDiscovery of RSV-induced BRD4 protein interactions using native immunoprecipitation and parallel accumulation – serial fragmentation (PASEF) mass spectrometry
Respiratory Syncytial Virus (RSV) causes severe inflammation and airway pathology in children and the elderly by infecting the epithelial cells of the upper and lower respiratory tract. RSV replication is sensed by intracellular pattern recognition receptors upstream of the IRF and NF-$\upkappa$B tr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-17 | PXD023983 | Pride
Human Ap-ms Brd4 Lung Rsv 
GenomicsRegulation of the KEAP1/NRF2 oxidative stress response pathway by BRD4 in prostate and colorectal cancer
To identify genes regulated by BRD4 and to provide insight into new mechanisms de-regulated by BRD4, such as the response to oxidative stress, we integrated BRD4-binding regions with BRD4 gene expression data. For this analysis we performed BRD4 chromatin immunoprecipitation experiments and BRD4 kn...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-50491 | biostudies-arrayexpress
ProteomicsProtein interactome analysis - Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation
The overall goal of the project was to identify proline hydroxylation dependent Brd4 interactome through label-free quantitative proteomics analysis.
ORGANISM(S): Homo sapiens (Human) 
2019-07-03 | PXD012633 | Pride
Brd4 Protein-protein interaction 
GenomicsHistone H4 acetylation and epigenetic reader Brd4 are critial regulators of pluripotency in embryonic stem cells
Histone H4ac and Brd4 are critical for ESCs 12 samples: 2 replicates for each ChIP, 2 replicates for each input sample.
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-76760 | biostudies-arrayexpress
GenomicsBromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells
Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with Bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-33281 | biostudies-arrayexpress
ProteomicsBRD4 IP MS in leukemia - MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation
The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1. W...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD012715 | Pride
Leukemia Mthfd1 Complex Brd4 
TranscriptomicsThe bromodomain protein BRD4 regulates splicing during heat shock
During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress
TranscriptomicsBrd4 regulation of activity dependent transcription
Inhibition of Brd4 with Jq1 in neurons with or without BDNF stimulation Examination of the effects of Jq1 treatment on primary mouse cortical neurons
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-63809 | biostudies-arrayexpress
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