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TranscriptomicsMthfd1 is a modifier of intestinal carcinogenesis
The metabolic pathways that underlie the association between folate deficiency and increased risk for colorectal cancer (CRC) remain unclear. We have studied the effect of C1THF synthase (encoded by the Mthfd1 gene) and dietary folate and choline on intestinal tumor development in Apcmin/+ mice and ...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-15419 | biostudies-arrayexpress
ProteomicsBRD4 IP MS in leukemia - MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation
The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1. W...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD012715 | Pride
Leukemia Mthfd1 Complex Brd4 
GenomicsMTHFD1 links folate metabolism to BRD4-mediated transcriptional regulation
MTHFD1 links folate metabolism to BRD4-mediated transcriptional regulation
PRJNA415413 | ENA
Methylation profilingMTHFD1 controls DNA methylation in Arabidopsis
In order to further investigate silencing mechanisms, we screened a mutagenized Arabidopsis thaliana population for expression of SDCpro-GFP, redundantly controlled by DNA methyltransferases DRM2 and CMT3. We identified the hypomorphic mutant mthfd1-1, carrying a mutation (R175Q) in the cytoplasmic ...
ORGANISM(S): Arabidopsis thaliana 
2016-06-07 | GSE77966 | GEO
TranscriptomicsMthfd1 is a modifier of intestinal carcinogenesis
The metabolic pathways that underlie the association between folate deficiency and increased risk for colorectal cancer (CRC) remain unclear. We have studied the effect of C1THF synthase (encoded by the Mthfd1 gene) and dietary folate and choline on intestinal tumor development in Apcmin/+ mice and ...
ORGANISM(S): Mus musculus 
2010-03-20 | GSE15419 | GEO
GenomicsMTHFD1 links folate metabolism to BRD4-mediated transcriptional regulation
The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for functional regulators and physical interactors of BRD4, which converge on the folate pathway en...
ORGANISM(S): Homo sapiens 
2019-04-04 | GSE105786 | GEO
UnknownMTHFD1 controls DNA methylation in Arabidopsis.
Not available
S-EPMC4909953 | biostudies-literature
GenomicsEffect of adenosine treatment on HAP1 cells with a knockout of MTHFD1
Effect of adenosine treatment on HAP1 cells with a knockout of MTHFD1
PRJNA830886 | ENA
ProteomicsChromatin isolation for mass spectrometry
The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1. W...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD013090 | Pride
Transcription Brd4 Mthfd1 Folate metabolism Gene regulation 
UnknownMthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Not available
S-EPMC3047240 | biostudies-literature
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