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Proteomics: Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular details of BRD4 regulation remain largely unknown. Here, we report that PRMT2- and PRMT4-med...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD034650 | Pride
Transcription Dna repair Arginine methylation Prmt2/4 Brd4 
GenomicsArginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
PRJNA851739 | ENA
TranscriptomicsArginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular details of BRD4 regulation remain largely unknown. Here, we report that PRMT2- and PRMT4-med...
ORGANISM(S): Homo sapiens 
2022-12-14 | GSE206667 | GEO
UnknownArginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair.
Not available
S-EPMC9728970 | biostudies-literature
UnknownLoss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice.
Not available
S-EPMC9283439 | biostudies-literature
UnknownPRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6.
Not available
S-EPMC10765854 | biostudies-literature
UnknownPADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma.
Not available
S-EPMC11904308 | biostudies-literature
MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
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