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TranscriptomicsSublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human polymorphonuclear leukocyte gene expression and enhance bactericidal capacity.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are often caused by strains encoding Panton-Valentine leukocidin (PVL). PVL can cause lysis of polymorphonuclear leukocytes (PMNs) and other myeloid cells in vitro, a function considered widely as the primary means...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
TranscriptomicsPanton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA
Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect ba...
ORGANISM(S): Staphylococcus aureus 
2010-06-19 | E-GEOD-8677 | biostudies-arrayexpress
TranscriptomicsS. aureus gene expression during growth phase and/or S. aureusâ??PMN interaction
To measure S. aureus gene expression during growth phase and/or S. aureusâ??PMN interaction.
ORGANISM(S): Staphylococcus aureus 
2010-06-09 | E-GEOD-2728 | biostudies-arrayexpress
TranscriptomicsGlobal changes in Staphylococcus aureus gene expression in human blood provide insight into mechanisms of immune evasion and virulence
Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote bacteremia and survival in human blood is ...
ORGANISM(S): Staphylococcus aureus 
2011-08-25 | E-GEOD-25454 | biostudies-arrayexpress
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