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MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
TranscriptomicsTranscriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
Hepatic stellate cells are involved in the development of hepatic fibrosis. We here perform transcriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in ...
ORGANISM(S): Mus musculus 
2019-04-07 | E-MTAB-7054 | biostudies-arrayexpress
UnknownDesigning an AI companion to support informal caregivers in role transition: insights from a design science approach.
Not available
S-EPMC12424210 | biostudies-literature
TranscriptomicsSubtype-dependent prognostic relevance of an interferon-induced pathway metagene in human node negative breast cancer
We identified and validated the pivotal role for a metagene containing IFN-induced genes in association to higher metastatic potential as a function of the specific molecular subtype Fresh frozen primary tumors were collected at the time of diagnosis from 123 patients with operable breast cancer pre...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-37181 | biostudies-arrayexpress
TranscriptomicsInvestigating NAFLD from RNA-seq data (human cell line Huh7) for samples under three treatments: low fat low sugar, low fat high sugar and high fat high sugar. Wild type samples are compared against DGAT2 knocked out.
Non-alcoholic fatty liver disease (NAFLD) is a major public health burden and it covers a spectrum of diseases. NAFLD starts with the accumulation of lipid droplets (LDs) within hepatocytes (steatosis). Part of the challenge of studying the mechanistic processes involved in LD accumulation and their...
ORGANISM(S): Homo sapiens 
2020-08-21 | E-MTAB-7884 | biostudies-arrayexpress
UnknownCharge-Induced Disorder Controls the Thermal Conductivity of Entropy-Stabilized Oxides.
Not available
S-EPMC9486463 | biostudies-literature
TranscriptomicsGene expression profiling of FFPE breast cancer samples [Illumina DASL WG platform]
The use of Affymetrix U133 2.0 Plus chips on FFPE samples when coupled with a qPCR-based sample pre-assessment step, yielded satisfactory results from the point of view of biological reliability. When compared with the Illumina DASL WG platform, specifically designed for degraded RNA, the data gener...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-GEOD-51451 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of FFPE breast cancer samples [Affymetrix vs. Illumina]
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-02-25 | E-GEOD-51452 | biostudies-arrayexpress
TranscriptomicsEffects of bacterium Burkholderia phytofirmans PsJN in Arabidopsis
Plant growth promoting rhizobacteria (PGPR) induce positive effects in plants, such as increased growth or reduced stress susceptibility. The mechanisms behind PGPR/plant interaction are poorly understood, as most studies have described short- term responses on plants and only a few studies have ana...
ORGANISM(S): Arabidopsis thaliana 
2013-05-31 | E-GEOD-47092 | biostudies-arrayexpress
UnknownIs oxygen availability a limiting factor for in vitro folliculogenesis?
Not available
S-EPMC5806880 | biostudies-literature
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