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ProteomicsDissecting the RAD51–BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics
The interaction between the RAD51 and BRCA2 proteins is central to homologous recombination (HR), a crucial pathway ensuring high-fidelity DNA repair. Recruitment of RAD51 involves eight highly conserved regions on BRCA2, named BRC repeats. The interaction between the fourth BRC repeat (BRC4) and th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-29 | PXD060867 | Pride
ProteomicsProteomic profile of BxPC3 cells after RAD51 inhibition by treatment with BRC4
RAD51 protein is an evolutionarily conserved recombinase that plays a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. RAD51 inactivation by small molecules has been proposed as a strategy to impair the BRCA2/RAD51 binding and, ultimately, the HR pathway, with ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042696 | Pride
Proteomie Rad51 Bxpc3 cells Brc4. 
UnknownDissecting the RAD51-BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics.
Not available
S-EPMC12606624 | biostudies-literature
UnknownHigh levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells.
Not available
S-EPMC4194320 | biostudies-literature
UnknownImprovement of nuclear facilities DNP3 protocol data transmission security using super encryption BRC4 in SCADA systems.
Not available
S-EPMC8594588 | biostudies-literature
UnknownContributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.
Not available
S-EPMC3799448 | biostudies-literature
UnknownThe Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination.
Not available
S-EPMC9368738 | biostudies-literature
UnknownDesign of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.
Not available
S-EPMC2917172 | biostudies-literature
UnknownA mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
Not available
S-EPMC3145889 | biostudies-literature
UnknownIdentification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry.
Not available
S-EPMC9377020 | biostudies-literature
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