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ProteomicsTandem affinity purification coupled with mass spectrometry (TAP-MS) to identify the proteins that interact with RAD51, RAD51 paralogs (RAD51B, RAD51C,RAD51D,XRCC2 and XRCC3), PFKP and PFKP-F649L in HeLa cells.
Tandem affinity purification coupled with mass spectrometry (TAP-MS) was used to identify the proteins that interact with RAD51,RAD51 paralogs (RAD51B, RAD51C,RAD51D,XRCC2 and XRCC3),PFKP and PFKP-F649L in HeLa cells. In addition, we also investigated the phosphorylation of RAD51.
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD070095 | Pride
Rad51paralogs Rad51 Pfkp-f649l Hela cells Rad51 phosphorylation Pfkp 
TranscriptomicsRad51 binding in meiosis after undergoing S phase with different replication programs.
ChIP-on-chip analysis of Rad51 binding in cells induced to undergo synchronous meiosis after growth in continuous nitrogen-rich conditions or after nitrogen depletion. Comparison of pat1-114 cells grown in -N and +N conditions as well as pat1-114 cells with altered Cdc45 levels in -N conditions. pat...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-20 | E-GEOD-53880 | biostudies-arrayexpress
ProteomicsDissecting the RAD51–BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics
The interaction between the RAD51 and BRCA2 proteins is central to homologous recombination (HR), a crucial pathway ensuring high-fidelity DNA repair. Recruitment of RAD51 involves eight highly conserved regions on BRCA2, named BRC repeats. The interaction between the fourth BRC repeat (BRC4) and th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-29 | PXD060867 | Pride
GenomicsTranscriptionally active chromatin channels DNA double-strand breaks to RAD51-dependent repair
Cells have developed effective mechanisms, namely homologous recombination (HR) and non-homologous end-joining (NHEJ), to repair DNA double-strand breaks (DSBs), which are considered to be the most deleterious type of damage that can challenge genome integrity. While these pathways coexist to repair...
ORGANISM(S): Homo sapiens 
2014-03-23 | E-MTAB-1241 | biostudies-arrayexpress
ProteomicsBreaking new ground into RAD51–BRC repeats interplay in Homologous Recombination
Homologous recombination (HR) is a critical repair pathway involving numerous proteins that ensure error-free repair of DNA double-strand breaks (DSBs). Dysfunction in HR components can compromise genome integrity. Despite advances, many aspects of HR remain poorly understood. Notably, even one of t...
ORGANISM(S): Escherichia coli 
2026-09-09 | PXD065998 | Pride
Brca2 Breast cancer Rad51 Crosslinking 
TranscriptomicsEffect of ARF on the transcription of p53 target genes in homologous recombination deficient cells
ARF is a tumour suppressor activated by oncogenic stress, which stabilizes p53. Although p53 is a key component of the response to DNA damage, a similar function for ARF has not been ascribed. In this work we show that homologous recombination (HR) -deficient primary mouse and human cells accumulate...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-51354 | biostudies-arrayexpress
ProteomicsMechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs). The DSBs are resected to yield single-stranded DNA (ssDNA) that are coated by Replication Protein A (RPA). Rad51 is a recombinase and catalyzes strand invasion and the search for homology. However, it binds to ssDNA with lower ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-28 | PXD065573 | Pride
Cross-linking Lc-msms 
GenomicsRAD51 knockout in murine liver (11-week)
RAD51 knockout in murine liver (11-week)
PRJNA1019697 | ENA
GenomicsRAD51 knockout in murine liver (4-week)
RAD51 knockout in murine liver (4-week)
PRJNA1019234 | ENA
ProteomicsProteomic profile of BxPC3 cells after RAD51 inhibition by treatment with BRC4
RAD51 protein is an evolutionarily conserved recombinase that plays a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. RAD51 inactivation by small molecules has been proposed as a strategy to impair the BRCA2/RAD51 binding and, ultimately, the HR pathway, with ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042696 | Pride
Proteomie Rad51 Bxpc3 cells Brc4. 
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