Brd4 degradation

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CHEBI ID

CHEBI:167608 (1)
CHEBI:167606 (1)
CHEBI:49728 (1)
CHEBI:17877 (1)
CHEBI:88378 (1)
CHEBI:18381 (1)
CHEBI:47013 (1)
CHEBI:35145 (1)
CHEBI:40595 (1)
CHEBI:89698 (1)
CHEBI:17973 (1)
CHEBI:16287 (1)
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CHEBI:67119 (1)
CHEBI:17485 (1)
CHEBI:35374 (1)
CHEBI:32796 (1)
CHEBI:16938 (1)
CHEBI:46905 (1)
CHEBI:18009 (1)
CHEBI:16332 (1)
CHEBI:17713 (1)
CHEBI:17553 (1)
CHEBI:32797 (1)
CHEBI:15713 (1)
CHEBI:16264 (1)
CHEBI:17659 (1)

Metabolite Name

Leucine (2)
Citrulline (2)
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Methionine (2)
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Hexenoylcarnitine (Car(6:1)) (1)
4-(Dimethylamino)pyridine (1)
1-Octadecylamine (1)
1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine (1)
1-Hexadecylamine (1)
2,4,6-Trimethylpyridine (1)
N-Oleoyl-D-erythro-sphingosylphosphorylcholine (1)
Oxotetradecadienoylcarnitine (Car(14:3-O)) (1)
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine (1)
1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (1)
[(Aminocarbonyl)(methyl)amino]acetic acid (1)
2-(2-Aminoethoxy)acetic acid (1)
Tetradecenedioylcarnitine (Car(14:1-O2)) (1)

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Study type

Transcription profiling by array (148)
RNA-seq of coding RNA (33)
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ChIP-seq (14)
Other (8)
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DNA-seq (3)
Animal - High-throughput sequencing (2)
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GRO-seq (1)
Human - High-throughput sequencing (1)
MBD-seq (1)
MicroRNA profiling by array (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2010 (39)
2013 (29)
2025 (28)
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2023 (27)
2012 (26)
2022 (25)
2015 (25)
2008 (25)
2021 (22)
2007 (22)
2014 (18)
2020 (16)
2016 (16)
2019 (14)
2011 (13)
2026 (12)
2018 (12)
2017 (12)
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2004 (4)
2005 (3)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
University of Dundee, Scool of Life Sciences, Department of Molecular, Cellular andDevelopmental biology (2)
Dana-Farber Cancer Institute 450 Brookline Avenue, Longwood Center 3217 Boston, MA 02215 (1)
Department of Chemistry Northwestern University (1)
Dr Georg E. Winter, Winter Lab, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (1)
EF-SM-LH5, Merck KGaA (1)
Medicinal Chemistry, Monash Institute of Pharmaceutica Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia (1)
Professor Centre for Targeted Protein Degradation, School of Life Sciences, university of Dundee (1)
School of Life Science, Peking University (1)
School of Pharmacy, University of Wisconsin-Madison (UW-Madison) (1)
The Scripps Research Institute, Department of Chemistry (1)
University of Dundee, School of Life Sciences, Department of molecular, cellular and developmental biology (1)

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Streptococcus anginosus promotes hepatocellular carcinoma progression and BET inhibitor resistance by inducing BRD4 lactylation

Hepatocellular carcinoma (HCC) is a highly aggressive form of carcinoma with a poor prognosis. Diagnostic markers and potential therapeutic targets for HCC are urgently needed. Here, we demonstrate that fecal microbiota transplantation (FMT) using stool samples from HCC patients significantly pro...

2025-12-05 | MTBLS12398 | MetaboLights

BRD4 degradation via stabilization of a native interaction with DCAF16

Targeted protein degradation is a modality based on small molecules that induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase, thus prompting POI ubiquitination and degradation. To expand the reach of TPD, current research is geared to unlock novel E3s. To that end, the tr...

ORGANISM(S): Homo sapiens (Human)

2024-01-08 | PXD040570 | Pride

Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release

Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...

ORGANISM(S): Homo sapiens

2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress

P53-P21-RB pathway promotes BRD4 degradation in liver cancer through decreasing USP1 transcription

PRJNA1020749 | ENA

BET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [CUT&RUN]

PRJNA1468760 | ENA

BET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [RNA-Seq]

PRJNA1469055 | ENA

Bardoxolone conjugation enables targeted protein degradation of BRD4.

Not available

S-EPMC7511954 | biostudies-literature

BRD4 degradation in CSCs

PRJNA1099160 | ENA

Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.

Not available

S-EPMC11960843 | biostudies-literature

Chip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells

BRD4-NUT megadomains is an order of magnitude larger than super-enhancer regions and displays a more continuously enriched profile rather than appearing as a cluster of individual peaks. Chip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells

ORGANISM(S): Homo sapiens

2015-07-14 | E-GEOD-70870 | biostudies-arrayexpress

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