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GenomicsChip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells
BRD4-NUT megadomains is an order of magnitude larger than super-enhancer regions and displays a more continuously enriched profile rather than appearing as a cluster of individual peaks. Chip-seq mapping of active chromatin marks in BRD4-NUT and different NMC cells
ORGANISM(S): Homo sapiens 
2015-07-14 | E-GEOD-70870 | biostudies-arrayexpress
ProteomicsOncogenic BRD4-NUT protein interactions
To investigate the mechanism that drives dramatic mistargeting of active chromatin in NUT midline carcinoma, we have identified protein interactions unique to the BRD4-NUT fusion oncoprotein compared to wild type BRD4. Using crosslinking, affinity purification, and mass spectrometry, we identified ...
ORGANISM(S): Homo sapiens (Human) 
2017-04-05 | PXD005786 | Pride
Biotap-xl Znf532-nut Hyperacetylation Topological domains 
GenomicsBET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [CUT&RUN]
BET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [CUT&RUN]
PRJNA1468760 | ENA
GenomicsBET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [RNA-Seq]
BET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [RNA-Seq]
PRJNA1469055 | ENA
UnknownPerturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma.
Not available
S-EPMC3149357 | biostudies-literature
GenomicsChIP-seq analysis of BRD4-NUT and H3K27ac distribution in NUT Carcinoma cell line TC-797 treated with DMSO or Panobinostat
ChIP-seq analysis of BRD4-NUT and H3K27ac distribution in NUT Carcinoma cell line TC-797 treated with DMSO or Panobinostat
PRJNA744553 | ENA
GenomicsBrd4::Nutm1 fusion gene initiates NUT carcinoma in vivo [RNA-seq]
Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo [RNA-seq]
PRJNA1098066 | ENA
GenomicsCombined targeting of the BRD4-NUT-p300 axis in NUT midline carcinoma by dual selective bromodomain inhibitor, NEO2734
Combined targeting of the BRD4-NUT-p300 axis in NUT midline carcinoma by dual selective bromodomain inhibitor, NEO2734
PRJNA597130 | ENA
GenomicsBET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [CUT&RUN]
BET bromodomain inhibitors block binding of bromodomain 1 and 2 (BD1, BD2) of BET family proteins to chromatin, and have demonstrated clinical on-target activity in NUT carcinoma (NC), a BRD-NUT fusion oncoprotein-driven cancer. However, toxicity due to inhibition of BD1 has limited the effectivenes...
ORGANISM(S): Homo sapiens 
2026-09-14 | GSE332674 | GEO
TranscriptomicsBET bromodomain 2 inhibition couples chromatin displacement to SPOP-mediated BRD4/BRD4-NUT degradation, defining a therapeutic vulnerability in NUT carcinoma [RNA-Seq]
BET bromodomain inhibitors block binding of bromodomain 1 and 2 (BD1, BD2) of BET family proteins to chromatin, and have demonstrated clinical on-target activity in NUT carcinoma (NC), a BRD-NUT fusion oncoprotein-driven cancer. However, toxicity due to inhibition of BD1 has limited the effectivenes...
ORGANISM(S): Homo sapiens 
2026-09-14 | GSE332774 | GEO
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