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MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
TranscriptomicsAnalyses of Human Brain Metastases of Breast Cancer Reveal the Association between HK2 Up-Regulation and Poor Prognosis
Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis. Brain metastases of breast cancer seem to be increasing in incidence as systemic therapy improves. Metastatic disease in the brain is associated with high mor...
ORGANISM(S): Homo sapiens 
2010-01-21 | E-GEOD-20016 | biostudies-arrayexpress
TranscriptomicsBreast Brain Metastasis, Non-Neoplastic Brain, and Non-Neoplastic Breast Gene Expression
The central nervous system (CNS) is a common site of metastatic disease in patients with breast cancer and has few therapeutic options with dismal outcomes. The purpose of our study was to identify common and rare events that underlie breast cancer CNS metastasis. We performed deep genomic profiling...
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-52604 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer brain metastases in a mouse xenograft model with vehicle of vorinostat treatment
Gene Expression Profiling of a Mouse Xenograft Model of â??Triple-Negativeâ?? Breast Cancer Brain Metastases With and Without Vorinostat Treatment. Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few...
ORGANISM(S): Homo sapiens 
2009-10-27 | E-GEOD-18544 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary breast tumors
Brain metastasis is one of the most feared complications of cancer and the most common intracranial malignancy in adults. Its underlying mechanisms remain unknown. From breast cancer patients with metastatic disease we isolated cell populations that aggressively colonize the brain. Transcriptomic an...
ORGANISM(S): Homo sapiens 
2009-06-23 | E-GEOD-12276 | biostudies-arrayexpress
ProteomicsT Lymphocytes induce the expression of Coronin-1A in breast cancer cells enabling the transmigration through a blood-brain-barrier model
Background: In previous work we discovered that T lymphocytes play a prominent role in the rise of brain metastases of ER-negative breast cancers. In the present study we explored expressional changes due to T cell contact associated with penetration through the BBB for breast cancer cell lines deri...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD053787 | Pride
Breast cancer  brain metastasis  blood-brain barrier  proteomics  liquid chromatography-mass spectrometry  coronin-1a 
GenomicsBreast cancer brain metastasis
Breast cancer brain metastasis
PRJNA970206 | ENA
ProteomicsComparative Membrane Proteomics Analyses of Breast Cancer Cell Lines to Understand the Molecular Mechanism of Breast Cancer Brain Metastasis
Breast cancer is the leading type of cancer in women. Breast cancer brain metastasis is considered as an essential issue in breast cancer patients. Membrane proteins play important roles in breast cancer brain metastasis that contributes to the cell adhesion and penetration of blood-brain barrier. T...
ORGANISM(S): Homo sapiens (Human) 
2017-05-23 | PXD005719 | Pride
Proteomics Breast cancer brain metastasis Membrane enrichment Differential expression analysis Lc-ms/ms 
TranscriptomicsTranscription profiling of human normal, non-tumorigenic breast cancer cells and CD44+CD24-/low tumorigenic breast cancer cells to generate a invasiveness gene signature
Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels of CD24 (CD44+CD24-/low) that have higher tumorigenic capacity than other subtypes of cancer cells. METHODS: We compared the gene-expression profile of CD44+CD24-/low tumorige...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-6883 | biostudies-arrayexpress
ProteomicsT cells facilitate brain metastasis of breast cancer.
Three breast cancer cell lines were co-cultured with T cells isolated from normal donors, in 3: 1 ratio. As controls, the breast cancer cells were cultured without T cells for three days. All cell cultures were washed three times with PBS to remove T cells before they were scraped and collected in 1...
ORGANISM(S): Homo sapiens (Human) 
2018-01-24 | PXD006750 | Pride
Breast cancer T cell response Human. Brain metastasis 
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