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MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
MetabolomicsA metabolomic study of urinary changes in type 2 diabetes in human compared to the control group
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in ...
2012-02-14 | MTBLS1 | MetaboLights
Genomicshuman gut metagenome
Human Gut Metagenome
PRJNA287290 | ENA
GenomicsEvolutionary Significance of DNA Methylation in Human and Chimpanzee Brains
We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated am...
ORGANISM(S): Human 
2012-09-04 | E-GEOD-37202 | biostudies-arrayexpress
MetabolomicsImproving the Screening Analysis of Pesticide Metabolites in Human Biomonitoring by Combining High-Throughput In Vitro Incubation and Automated LC-HRMS Data Processing
There is a current need to monitor human exposure to a large number of pesticides and other chemicals of emerging concern (CECs). This requires screening analysis with high confidence for these compounds and their metabolites in complex matrices, which is hampered by the fact that no reference stand...
2022-01-17 | MTBLS2402 | MetaboLights
TranscriptomicsLow dose human chorionic gonadotropin hCG
Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose h...
ORGANISM(S): Homo sapiens 
2010-10-02 | E-GEOD-18557 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of human lung
The proteome in human lung was identified by mass spectrometry and quantified by label free method
ORGANISM(S): Homo Sapiens 
PXD036439 |
TranscriptomicsTranscription profiling of human induced pluripotent stem cells signature and memory retention
Transient expression of two factors, or from Oct4 alone, resulted in efficient generation of human iPSCs. The reprogramming strategy described revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and...
ORGANISM(S): Homo sapiens 
2009-12-19 | E-GEOD-18618 | biostudies-arrayexpress
Genomicshuman metagenome
Human Microbiome Project (HMP) Metagenomic WGS Projects, deeper sequencing of the human microbiome samples: Production Phase
PRJNA48479 | ENA
ProteomicsGlobal Profiling of the Lysine Lactylation in Human Lung
LC-MS/MS for global profiling of lactylation in human lung under normal physiological conditions
ORGANISM(S): Homo Sapiens 
PXD036307 |
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