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MetabolomicsSerum metabolomic profiles identify ER-positive early breast cancer patients at increased risk of disease recurrence in a multicentre population

PURPOSE: Detecting signals of micrometastatic disease in early breast cancer (EBC) patients could improve risk stratification and allow better tailoring of adjuvant therapies. We have previously shown that postoperative serum metabolomic profiles are predictive of relapse in a si...

2017-03-02 | MTBLS424 | MetaboLights
MetabolomicsFermented brewers' grains modulate serum and pectoral muscle metabolome to regulate flavor quality formation in broilers

This study was designed to systematically assess the impact of wet-fermented brewer's grains (WFBG) on pectoral muscle metabolic profiles and key regulatory pathways in broiler chickens. In this 21-day experiment, a total of 281 DEMs were identified, with 29 upregulated and 252 downregulated DEMs...

2026-05-27 | MTBLS14589 | MetaboLights
MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
TranscriptomicsRNA-seq of mRNA from MCF7 breast cancer cells and samples derived from normal breast tissues
To improve our understanding of the effect of differential methylation on gene expression between normal and tumor breast cells, we carried out RNA sequencing evaluate mRNA expression changes in normal breast tissue and MCF7 breast cancer cell line. We identified 6632 protein-coding genes to be sign...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-MTAB-1961 | biostudies-arrayexpress
MetabolomicsRBC Balanced Immuno-inflammatory Signatures Identify Advanced Breast Cancer Patients on CDK4/6 Inhibitors at Increased Risk of Progression and Death

Recent studies show red blood cell (RBC) plays an essential role in regulating immunity. Nevertheless, the association of immuno-inflammatory parameters, especially RBC balanced signatures, with survival outcomes and adverse events still require investigation for advanced breast cancer (ABC) pati...

2025-04-15 | MTBLS10792 | MetaboLights
ProteomicsEffect of an immune challenge and feed supplements on broiler chicken individual breast muscle protein synthesis
Optimization of broiler chicken breast muscle protein accretion is key for the efficient production of poultry meat, whose demand is steadily increasing. In a context where antimicrobial growth promoters use is being restricted, it is important to find alternatives as well as to characterize the eff...
ORGANISM(S): Gallus gallus (Chicken) 
2024-04-04 | PXD044325 | Pride
Chicken Citrus Fsr Muscle 
MetabolomicsA Divergent Selection on Breast Meat Ultimate pH, a Key Factor for Chicken Meat Quality, is Associated With Different Circulating Lipid Profiles

BACKGROUND: Chicken meat has become a major source of protein for human consumption. However, the quality of the meat is not yet under control, especially since pH values that are too low or too high are often observed. In an attempt to get a better understanding of the genetic a...

2022-06-01 | MTBLS2970 | MetaboLights
TranscriptomicsTranscriptome profile analysis of breast muscle tissues from high or low levels of atmospheric ammonia exposed broilers (Gallus gallus)
Abstract: Atmospheric ammonia is a common problem in poultry industry. High concentrations of aerial ammonia cause great harm to broilers' health and production. For the consideration of human health, the limit exposure concentration of ammonia in houses is set at 25 ppm. Previous reports have shown...
ORGANISM(S): Gallus gallus 
2016-08-19 | E-GEOD-85786 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of post-hatch breast muscle in legacy and modern broiler chickens reveals enrichment of several regulators of myogenic growth
We report the results of comparative transcriptional profiling in the pectoralis major muscle of a modern production broiler line (Ross 708) and a legacy broiler line inbred since the late 1940s (Illinois) focusing on metabolic differences and differences in myogenic growth regulators Differential g...
ORGANISM(S): Gallus gallus 
2015-03-31 | E-GEOD-65217 | biostudies-arrayexpress
GenomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (ChIP-Seq)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40724 | biostudies-arrayexpress
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