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ProteomicsThe ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina
BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia. Its role in the retina remains poorly understood. This study provides a comprehensive...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD060682 | Pride
Bri23 Retina Retinal dystrophy Protein interactions Itm2b 
UnknownParallel in-register contact propensity predicts the Amyloidogenicity of ADan and ABri in familial dementias.
Not available
S-EPMC12817262 | biostudies-literature
GenomicsChIP-Seq of Arabidopsis wildtype inflorescences using an antibody raised against a C-terminal peptide of SEP3
WARNING: This library was yield low amount of material and it was over-amplified by PCR. This libraries are used study the robustness of several statitical methods against PCR artifacts. ChIP experiments were performed on Arabidopsis wildtype inflorescences using an antibody raised against a C-termi...
ORGANISM(S): Arabidopsis thaliana 
2011-04-27 | E-MTAB-587 | biostudies-arrayexpress
ProteomicsA Landscape of Ectodomain Shedding by Quantitative Protein Terminomics
Ectodomain shedding is a proteolytic process that regulates level and function of membrane proteins. By quantitative protein terminomics consisting of N- and C-terminal peptide enrichment, TMT-labeling and mass spectrometry, we quantified protein termini in the cultured media across 10 human cell li...
ORGANISM(S): Homo Sapiens (human) 
2021-03-05 | PXD021378 | JPOST Repository
ProteomicsOne-step Isolation of Protein C-terminal Peptides from Protease-digested Proteins by Metal Oxide-based Ligand Exchange Chromatography
We have developed a one-step method to isolate protein C-terminal peptides from V8-digested proteins by metal oxide-based ligand-exchange (MOLEX) chromatography. V8 protease cleaves the C-terminal side of Asp and Glu, and the resulting digested peptide has two carboxy groups at the C-terminus, where...
ORGANISM(S): Homo Sapiens (human) 
2021-12-28 | PXD027960 | JPOST Repository
ProteomicsGNA13 – peptide interaction analysis (GST-tag co-purification)
Alpha-1-antitrypsin (AAT), a circulating serine protease inhibitor, is an acute inflammatory response protein with anti-inflammatory functions. The C-terminal peptides of AAT are found in various tissues and have been proposed as putative bioactive peptides with multiple functions, but its mechanism...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2025-01-01 | PXD054789 | JPOST Repository
TranscriptomicsTranscriptomic and metabolomic analysis of Yukon Thellungiella plants grown in cabinets and their natural habitat
Background: Thellungiella salsuginea is an important model plant due to its natural tolerance to abiotic stresses including salt, cold, and water deficits. Microarray and metabolite profiling have shown that Thellungiella undergoes stress-responsive changes in transcript and organic solute abundanc...
ORGANISM(S): Thellungiella 
2012-10-22 | E-GEOD-41182 | biostudies-arrayexpress
GenomicsGenome-wide Runx1 binding sites in early hematopoietic progenitors (FDCP1)
We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81179 | biostudies-arrayexpress
TranscriptomicsExpression profiling of laser-microdissected tissue from Tg2576 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15056 | biostudies-arrayexpress
TranscriptomicsLaser-microdissected tissue from Tg2576 and APPPS1 plaque-depositing mouse model of Alzheimer's disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15128 | biostudies-arrayexpress
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