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ProteomicsFirst identification of ITM2B interactome in the human retina
ITM2B is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive demen...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020088 | Pride
Ap-ms Human Itm2b Retina Interactome 
ProteomicsIndentification of migrasome proteins regulated by ITM2B
We performed label-free quantitative proteomics to analyze migrasome proteins derived from ITM2B-knockdown 786-O cells and corresponding cells re-introduced with ITM2B1-115.
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD068814 | Pride
Itm2b Migrasome 
ProteomicsThe ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina
BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia. Its role in the retina remains poorly understood. This study provides a comprehensive...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD060682 | Pride
Bri23 Retina Retinal dystrophy Protein interactions Itm2b 
ProteomicsIdentification of ITM2B I115A binding proteins
ITM2B, a transmembrane protein, is frequently undergoing cleavage. We found site I115 is essential for ITM2B cleavage and ITM2BI115A exhibited resistant to cleavage. Here, we identified the interaction proteins with full-length ITM2B through analysis of mass spectrum in ITM2BI115A expressing 786-O c...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD058330 | Pride
Ccrcc Itm2b 786-o cells 
ProteomicsLC-MS of migrasomes and vesicles form human ccRCC 786-O cells
On one hand, we performed label-free quantitative proteomics to analyze migrasome proteins derived from 786-O cells vs ITM2B-knockdown 786-O cells.On the other hands,we isolated ITM2B truncation-containing vesicles and performed mass proteomic analysis to identify proteins that were carried by ITM2B...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD054746 | Pride
Migrasome Vesicle Ccrcc 
UnknownFirst identification of ITM2B interactome in the human retina.
Not available
S-EPMC8390696 | biostudies-literature
UnknownITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth.
Not available
S-EPMC12822405 | biostudies-literature
UnknownInteraction Between ITM2B and GLUT9 Links Urate Transport to Neurodegenerative Disorders.
Not available
S-EPMC6818471 | biostudies-literature
UnknownInvestigating ITM2B-associated ataxia in a Taiwanese cerebellar ataxia cohort.
Not available
S-EPMC11752091 | biostudies-literature
UnknownThe ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.
Not available
S-EPMC4636210 | biostudies-literature
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