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Using RNA-Seq, we compared the transcriptomes of differentiated 3T3-L1 adipocytes for control and ZFP407-deficient cells Differentiated 3T3-L1 cells were electroporated with control or 1 of 2 Zfp407 siRNAs. Six independent siRNA electroporations were conducted for the control siRNA and 3 independent...
ORGANISM(S): Mus musculus 
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.
ORGANISM(S): Homo sapiens 
Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.
ORGANISM(S): Homo sapiens 
Tumour expression profiling was performed on resected brain tumour tissue following its histological categorisation. Classification of tumour type was carried out according to WHO criteria by a panel of independent pathologists across the etumour consorteum. This gave a high quality diagnostic eva...
ORGANISM(S): Homo sapiens 
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas and diffuse intrinsic pontine gliomas. The 450K methylation array is being used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of...
ORGANISM(S): Homo sapiens 
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