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TranscriptomicsGene expression profile of a murin neuroblastoma cell line infected with the prion strain 22L
The underlying pathogenic mechanisms of prion infection are not well characterized. To study the effect of prion infection on gene expression in neuronal cell cultures, a neuroblastoma (N2a) cell clone was infected with either the mouse adapted prion strain 22L or exposed to uninfected brain homogen...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7119 | biostudies-arrayexpress
TranscriptomicsActivating transcription factor 3 regulates immune and metabolic homeostasis
Integration of metabolic, stress and immune responses plays a fundamental role during animal development to maintain energy homeostasis while ensuring growth and proper developmental timing. Perturbation of metabolic and immune signaling circuits has detrimental consequences to animal development in...
ORGANISM(S): Drosophila melanogaster 
2012-11-05 | E-GEOD-36377 | biostudies-arrayexpress
MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
UnknownSMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment.
Not available
S-EPMC5938706 | biostudies-literature
UnknownAlterations of the endocannabinoid system in adolescents with non-suicidal self-injury as a function of childhood maltreatment.
Not available
S-EPMC11655887 | biostudies-literature
UnknownFeeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites.
Not available
S-EPMC5454507 | biostudies-literature
UnknownHigh fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis-inactivated Δ6-fatty acid desaturase-deficient mouse.
Not available
S-EPMC8479258 | biostudies-literature
ProteomicsERLIN1 and ERLIN2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
Complexes of ERLIN1 and ERLIN2 form large ring-like cup shaped structures on the endoplasmic reticulum (ER) membrane and serve as platform to bind cholesterol and E3-ubiquitin ligases, potentially defining functional nanodomains. Here, we show that ERLIN scaffolds mediate the interaction between the...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048503 | Pride
Erlin2 Tmub1 Drms Endoplasmic reticulum Hereditary spastic paraplegia Erlin1 Lipid rafts 
UnknownBovine Papillomavirus Type 1 or 2 Virion-Infected Primary Fibroblasts Constitute a Near-Natural Equine Sarcoid Model.
Not available
S-EPMC9781842 | biostudies-literature
UnknownActivating transcription factor 3 regulates immune and metabolic homeostasis.
Not available
S-EPMC3457521 | biostudies-literature
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