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ProteomicsERLIN1 and ERLIN2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
Complexes of ERLIN1 and ERLIN2 form large ring-like cup shaped structures on the endoplasmic reticulum (ER) membrane and serve as platform to bind cholesterol and E3-ubiquitin ligases, potentially defining functional nanodomains. Here, we show that ERLIN scaffolds mediate the interaction between the...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048503 | Pride
Erlin2 Tmub1 Drms Endoplasmic reticulum Hereditary spastic paraplegia Erlin1 Lipid rafts 
UnknownClustered hydrophobic amino acids in amphipathic helices mediate erlin1/2 complex assembly.
Not available
S-EPMC3242435 | biostudies-literature
UnknownTranscriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis.
Not available
S-EPMC8389572 | biostudies-literature
UnknownRaft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs.
Not available
S-EPMC8496542 | biostudies-literature
UnknownUsp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.
Not available
S-EPMC10914638 | biostudies-literature
UnknownERLIN1 mutations cause teenage-onset slowly progressive ALS in a large Turkish pedigree.
Not available
S-EPMC5945623 | biostudies-literature
ProteomicsUsp25-Erlin1/2 activity limits cholesterol flux to trigger TLR3 responses and restrict a broad range of viruses
Reprogramming lipid metabolic pathways is a critical feature of activating immune responses to infection. However, how these reconfigurations are regulated, particularly during virus infections are poorly understood. Our previous screen to identify cellular deubiquitylases activated during influenza...
ORGANISM(S): Homo sapiens (Human) Influenza A virus 
2026-02-09 | PXD034797 | Pride
Deubiquitylases Lipid metabolism Interaction proteomics Antiviral immunity 
UnknownBinding of the erlin1/2 complex to the third intralumenal loop of IP3R1 triggers its ubiquitin-proteasomal degradation.
Not available
S-EPMC9168715 | biostudies-literature
UnknownThe ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
Not available
S-EPMC3640729 | biostudies-literature
ProteomicsERLIN1 downregulation promotes tumor progression
Proteomic data of hypoxic HCC tissues and 97H ERLIN1 overexpressing HCC cell lines
ORGANISM(S): Homo Sapiens 
2025-04-24 | PXD063146 |
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