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GenomicsWhole genome methylation profiling in developing and developed Zebrafish
DNA methylation is a dynamic process through which specific chromatin modifications can be stably transmitted from parent to daughter cells. A large body of work has suggested that DNA methylation influences gene expression by silencing gene promoters. However, these conclusions were drawn from data...
ORGANISM(S): Danio rerio 
2014-03-25 | E-GEOD-52110 | biostudies-arrayexpress
ProteomicsDiversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain
Amyloid-beta (Aβ) plays a key role in the pathogenesis of Alzheimer’s disease (AD), but little is known about the proteoforms present in human AD brain. We used high-resolution mass spectrometry to analyze intact, undigested Aβ from purified soluble aggregates and insoluble material in brains of 6 c...
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD006552 | Pride
Post-translational modifications (ptms) Amyloid-beta Proteoforms Alzheimer’s disease Top-down mass spectrometry Truncations 
TranscriptomicsTranscription profiling of mouse strains responsive/unresponsive to asbestos backcrossed to either C57B or 129
Asbestos disease model: Occupational lung disease comprises a wide variety of disorders caused by the inhalation or ingestion of dust particles or noxious chemical. These disorders include pneumoconiosis, asbestos-related pleural and others. Although asbestos is carcinogenic to humans, the mech...
ORGANISM(S): Mus musculus 
2007-02-14 | E-TIGR-10 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease
Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-53789 | biostudies-arrayexpress
UnknownDeep-coverage whole genome sequences and blood lipids among 16,324 individuals.
Not available
S-EPMC6107638 | biostudies-literature
TranscriptomicsProtein profiling reveals five principal chromatin types in Drosophila cells
The local protein composition of chromatin is important for the regulation of transcription and other functions. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin typ...
ORGANISM(S): Drosophila melanogaster 
2010-10-01 | E-GEOD-22069 | biostudies-arrayexpress
MetabolomicsLimited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated...

2024-02-21 | MTBLS6677 | MetaboLights
UnknownStroke genetics informs drug discovery and risk prediction across ancestries.
Not available
S-EPMC9524349 | biostudies-literature
UnknownAberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Not available
S-EPMC10360040 | biostudies-literature
UnknownEpigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma.
Not available
S-EPMC10462855 | biostudies-literature
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