Whole genome methylation profiling in developing and developed Zebrafish

ABSTRACT: DNA methylation is a dynamic process through which specific chromatin modifications can be stably transmitted from parent to daughter cells. A large body of work has suggested that DNA methylation influences gene expression by silencing gene promoters. However, these conclusions were drawn from data focused mostly on promoter regions. With regards to the entire genome, it is unclear how methylation and gene transcription patterns are related during vertebrate development. To identify the genome-wide distribution of CpG methylation we created series of high-resolution methylome maps of Danio rerio embryos during development and in mature, differentiated tissues. We find that embryonic and terminal tissues have unique methylation signatures in CpG islands and repetitive sequences. Fully dif

ORGANISM(S): Danio rerio

SUBMITTER: Lawrence Brody 

PROVIDER: E-GEOD-52110 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress