Bromodomain containing proteins

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Unknown (287)
Genomics (162)
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Homo sapiens (143)
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Organisms

Homo sapiens (64)
Mus musculus (13)
Arabidopsis thaliana (2)
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Rattus norvegicus (1)
Saccharomyces cerevisiae (1)

Repository

biostudies-arrayexpress (124)
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geo (76)
pride (31)
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Disease

Acute leukemia (3)
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Technology Type

Mass Spectrometry (31)
Shotgun proteomics (16)
Affinity purification coupled with mass spectrometry proteomics (11)
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SWATH MS (2)
Mass spectrometry (1)
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DiaPASEF (1)
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TripleTOF 5600 (3)
NextSeq 500 (2)
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Illumina HiSeq 2000 (1)
Illumina HiSeq 3000 (1)
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Liquid Chromatography MS - alternating - hilic (1)

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2016 (34)
2015 (30)
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2013 (23)
2023 (20)
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2020 (9)
2022 (8)
2012 (8)
2021 (8)
2010 (7)
2025 (4)
2011 (2)
2009 (1)
2008 (1)

Metabolite Name

Hexenoylcarnitine (Car(6:1)) (1)
4-(Dimethylamino)pyridine (1)
1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine (1)
N-Oleoyl-D-erythro-sphingosylphosphorylcholine (1)
Arsenobetaine (1)
L-Norvaline (1)
Oxotetradecadienoylcarnitine (Car(14:3-O)) (1)
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine (1)
Imiquimod (1)
[(Aminocarbonyl)(methyl)amino]acetic acid (1)
2-(2-Aminoethoxy)acetic acid (1)
Alpinetin (1)
Ethyl 3-aminobenzoate (1)
2-Amino-3-methyl-imidazo[4,5-f]quinoline (IQ) (1)
1-Docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine (1)
Dihydrotachysterol (1)
Azeliragon (1)
Picoline (1)
Aminopicoline (1)
Tiglylcarnitine (Car(5:1)) (1)
Cysteine S-sulfate (1)
Fenobucarb (1)
Dibenzylamine (1)
Pyrimethanil (1)
N-Nitrosopyrrolidine (1)
Oxooctanoylcarnitine (Car(8:1-O)) (1)
.beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl (1)
Tetradecenedioylcarnitine (Car(14:1-O2)) (1)
Perifosine (1)
1-Octadecylamine (1)

First Public Date

2023 (17)
2021 (9)
2026 (8)
2017 (8)
2024 (7)
2020 (7)
2018 (7)
2016 (5)
2025 (4)
2022 (4)
2014 (4)
2019 (3)
2013 (3)
2015 (2)

Classification

protozoa (1)

Study type

ChIP-seq (47)
Transcription profiling by array (40)
RNA-seq of coding RNA (27)
ChIP-chip by tiling array (3)
Other (3)
Unknown experiment type (1)
Animal - High-throughput sequencing (1)
Genotyping by array (1)
Methylation profiling by high throughput sequencing (1)

Release Date

2016 (46)
2015 (44)
2014 (36)
2022 (35)
2021 (30)
2024 (26)
2013 (26)
2020 (25)
2018 (24)
2023 (21)
2017 (18)
2025 (15)
2019 (13)
2012 (11)
2010 (8)
2026 (5)
2011 (4)
2009 (4)
2007 (4)
2006 (4)
2008 (2)
2004 (2)
2003 (2)
2002 (2)
2001 (2)
2005 (1)
1997 (1)

Lab affiliation

Research Unit for Molecular Medicine, Department of clinical Medicine, Aarhus University, Aarhus, Denmark (5)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Dept. of Molecular Biosciences, University of Texas at Austin, Texas 78712 USA (2)
CRCL UMR Inserm U1052, CNRS 5286, UCBL, CLB (1)
Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain. (1)
Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain (1)
CeMM, Research Center for Molecular Medicine, Austrian Academy of Sciences, Austria (1)
Department of Biological Sciences, Vanderbilt University (1)
Department of precious medicine, University of Campania "L.Vanvitelli", vico L. de Crecchio 8, Naples, Italy (1)
Francis Crick Institute 1 Midland Road London NW1 1AT (1)
Institute for Clinical and Translational Research (ICTR), University of Wisconsin-Madison, Madison, WI, 53705, USA (1)
Institute for Clinical and Translational Research, University of Wisconsin - Madison (1)
Internal Medicine Morsani College of Medicine University of South Florida (1)
Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology (1)
Laboratory of Systems Biology, University of Warsaw (1)
Medicinal Chemistry, Monash Institute of Pharmaceutica Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia (1)
Molecular Oncology Moffitt Cancer Center Tampa, FL, USA (1)
Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla California 92037 USA (1)
Proteomics Facility, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany (1)
Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112 (1)
Research Unit for Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. (1)
Roivant sciences, Discovery Platform, Advanced simulations, New York City, NY (1)
Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research and Jewish General Hospital, and McGill University, Montréal, Québec, Canada Gerald Bronfman Department of Oncology, McGill University, Montréal, Québec, Canada (1)
Structural and Computational Biology Unit European Molecular Biology Laboratory Meyerhofstr. 1 69117 Heidelberg Germany (1)
The Drug Discovery Lab, Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA (1)

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Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with Bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...

ORGANISM(S): Homo sapiens

2012-11-14 | E-GEOD-33281 | biostudies-arrayexpress

Proteo-Genomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins (Chip-Seq data)

Background: Histone post-translational modifications (PTMs) constitute a branch of epigenetic mechanisms that can control the expression of eukaryotic genes in a heritable manner. Recent studies have identified several PTM-binding proteins containing diverse specialized domains whose recognition of ...

ORGANISM(S): Homo sapiens

2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (ChIP-Seq)

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved...

ORGANISM(S): Homo sapiens

2014-04-25 | E-GEOD-55062 | biostudies-arrayexpress

Histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins

Histone deacetylases (HDACs) and acetyltransferases control the epigenetic regulation of gene expression through modification of histone marks. Histone deacetylase inhibitors (HDACi) are small molecules that interfere with histone tail modification thus altering chromatin structure and epigeneticall...

ORGANISM(S): Homo sapiens (Human)

2015-03-18 | PXD001660 | Pride

Super-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins

Here, we investigate the role of enhancers in myofibroblasts, a cell type that dominates the pathogenesis and progression of tissue fibrosis. We reveal that bromodomain and extra-terminal family members (BETs), an important group of epigenetic readers, are critical for super-enhancer-mediated pro-fi...

ORGANISM(S): Homo sapiens

2015-12-11 | E-GEOD-58680 | biostudies-arrayexpress

Targeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...

ORGANISM(S): Homo sapiens

2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress

Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release

Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...

ORGANISM(S): Homo sapiens

2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress

BET bromodomain proteins regulate enhancer function during adipogenesis

PRJNA432392 | ENA

BET bromodomain containing epigenetic reader proteins regulate vascular smooth muscle cell proliferation and neointima formation

PRJNA575512 | ENA

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [ChIP-Seq]

Triple negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. Here we report the preferential and high sensitivity of TNBCs to BET bromodomain inhibitors such as JQ1 manifested by cell cycle arrest in early G1, apoptosis, and induct...

ORGANISM(S): Homo sapiens

2016-01-07 | E-GEOD-63581 | biostudies-arrayexpress

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621 Results

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