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The aim of this work is to apply an integrated systems approach to understand the biological underpinnings of hip osteoarthritis that culminates in the need for total joint replacement (TJR). This study is a feasibility pilot that integrates functional genomics data from diseased and non-diseased ti...
ORGANISM(S): Homo sapiens (Human) 
2018-05-14 | PXD006673 | Pride
Osteoarthritis, a serious joint disease for which we currently have no disease-stratifying or modifying therapy, causes pain and functional disability for almost a quarter of a billion people world-wide. In this study chondrocytes, synoviocytes and peripheral blood from 100 patients with osteoarthri...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD014666 | Pride
Osteoarthritis (OA) is a degenerative joint disease with a substantial health economic burden. There is no current treatment; instead, disease management targets the main symptoms (pain and stiffness) and culminates in joint replacement surgery. OA is a disease of cartilage degeneration, but the mol...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002014 | Pride
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