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TranscriptomicsConstitutive Expression of FevR (383) in wt, mglA mutant, and FevR mutant bacteria
Time courses and RNA isolation. Strains were created that constitutively express fevR (FTT0383) transcript by replacing the endogenous fevR promoter with that of groES, and this gro::fevR region was integrated into either the wild-type, mglA mutant (GB2), or fevR knockout. Overnight cultures of F. ...
ORGANISM(S): Francisella tularensis 
2009-01-05 | E-GEOD-11555 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of wild-type, mglA point mutant, and fevR (FTT0383) knockout bacteria
Time courses and RNA isolation. Overnight cultures of F. novicida strain U112, GB2, and fevR ko (383) were grown in TSB 0.2% cysteine at 37C with shaking and subcultured to an OD600 of 0.01 in 200ml. Samples were taken throughout the growth curve for RNA isolation and to determine the OD600. Fi...
ORGANISM(S): Francisella tularensis 
2009-01-05 | E-GEOD-11554 | biostudies-arrayexpress
TranscriptomicsIdentification of MglA-regulated genes reveals novel virulence factors in F. tularensis
The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo and this ability is essential for pathogenesis. The transcription factor MglA is required for expression of several Francisella genes that are...
ORGANISM(S): Francisella tularensis 
2010-07-01 | E-GEOD-5468 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Franscisella tuarensis to identify new virulence factors utilized by F. tularensis which causes the zoonotic disease tularemia
The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo and this ability is essential for pathogenesis. The transcription factor MglA is required for expression of several Francisella genes that are...
ORGANISM(S): Francisella tularensis 
2006-10-19 | E-SMDB-3741 | biostudies-arrayexpress
TranscriptomicsType I interferon signaling is required for activation of the inflammasome during Francisella infection
Francisella are pathogenic bacteria whose virulence is linked to their ability to replicate within the host cell cytosol. Entry into the macrophage cytosol activates a host protective multimolecular complex called the inflammasome to release the proinflammatory cytokines IL-1 and IL-18 and trigger c...
ORGANISM(S): Mus musculus 
2007-05-23 | E-GEOD-7684 | biostudies-arrayexpress
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