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GenomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity
We performed ChIP-seq to chart genome-wide maps of H3K27me3 in brown preadipocytes and mature brown adipocytes. We observed a subset of brown fat-specific genes, but not common fat genes or white fat-specific genes, possess the H3K27me3 mark in preadipocytes, and this mark is erased in mature adipoc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-55469 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat chronic exposure to cigarette smoke
Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, w...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7079 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in lung tissue of rats following exposure to mainstream cigarette smoke
Expression data from rats exposed to cigarette smoke (CS) at three concentrations (sham, 300 µgTPM/l and 600 µgTPM/l) for 13 weeks (5d/week; 2hrs/day) after three different recovery times (2hrs, 6hrs and 20hrs after last treatment); lung tissue Keywords: recovery time course and dose dependency Male...
ORGANISM(S): Rattus norvegicus 
2006-07-27 | E-GEOD-4516 | biostudies-arrayexpress
UnknownBrown Seaweed Sargassum siliquosum as an Intervention for Diet-Induced Obesity in Male Wistar Rats.
Not available
S-EPMC8224310 | biostudies-literature
MetabolomicsAlterations in fecal metagenomics and serum metabolomics indicate management strategies for patients with Budd-Chiari syndrome

OBJECTIVES: We investigated the effects of gut microbiota and serum metabolic levels on the patients with Budd-Chiari syndrome (B-CS), and their guidance for clinical management strategies.

DESIGN: 214 B-CS subjects including untreated case (n=93) and treat...

2021-10-20 | MTBLS2319 | MetaboLights
MetabolomicsA female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametoc...
2016-09-14 | MTBLS98 | MetaboLights
UnknownHeterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells.
Not available
S-EPMC6531810 | biostudies-literature
UnknownMurine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E.
Not available
S-EPMC4256255 | biostudies-literature
UnknownThe prevalence and predictors of active brown adipose tissue in Chinese adults.
Not available
S-EPMC4127998 | biostudies-literature
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